目的 研究三九膏的體外透皮吸收規(guī)律。方法 通過Franz擴(kuò)散池獲得接收液，采用HPLC法測(cè)定芥子堿硫氰酸鹽，計(jì)算三九膏的體外透皮吸收的累積滲透率，探究其擬合模型。結(jié)果 三九膏中芥子堿硫氰酸鹽12 h的累積滲透率在22%左右，體外透皮吸收規(guī)律符合希古契模型。結(jié)論 三九膏中芥子堿硫氰酸鹽累積透過量在時(shí)間上與臨床治療貼敷時(shí)間吻合，為三九膏臨床治療確定最適宜貼治時(shí)間提供了依據(jù)。

Objective To study the absorption propertied of Sanjiu Plaster in vitro. Methods Franz diffusion pool was used to obtain receptor fluid, and sinapine thiocyanate was determined by HPLC method. Cumulative permeability was calculated to find out its fitting model. Results Cumulative permeability of sinapine thiocyanate from Sanjiu Plaster during 12 h was about 22%. The characteristics was accord to Higuhci fitting model in vitro. Conclusion Cumulative penetration amounts of sinapine thiocyanate in Sanjiu Plaster had the same period of time with sticking time, which can provide the basis for treatment. Key word:Sanjiu Plaster; sinapine thiocyanate; percutaneous absorption; dynamical model