目的 比較前列地爾與法舒地爾治療急性腦梗死的臨床療效。方法 選取2013年1月-2015年7月榆林市第一醫(yī)院收治的急性腦梗死患者92例，隨機(jī)分為對(duì)照組（44例）和治療組（48例）。對(duì)照組靜脈滴注鹽酸法舒地爾注射液，60 mg加入到生理鹽水250 mL中，1次/d。治療組靜脈滴注前列地爾注射液，20 μg加入到生理鹽水250 mL中，1次/d。兩組患者均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組NISS評(píng)分、正五聚體蛋白3（PTX-3）及頸動(dòng)脈粥樣斑塊的變化。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為77.3%、93.8%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組NISS評(píng)分均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組NISS評(píng)分的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組PTX-3均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組PTX-3的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組斑塊形成率顯著下降，而穩(wěn)定斑塊比例上升，治療組同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。對(duì)照組和治療組斑塊形成率分別為35.4%、56.8%，穩(wěn)定斑塊所占比例分別為52.0%、94.1%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 前列地爾治療急性腦梗死具有較好的臨床療效，可改善臨床癥狀，降低PTX-3，提高斑塊穩(wěn)定性，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To compare clinical curative effect of alprostadil and fasudil in treatment of acute cerebral infarction. Methods Patients (92 cases) with acute cerebral infarction in the First Hospital of Yulin City from January 2013 to July 2015 were randomly divided into control group (44 cases) and treatment group (48 cases). Patients in the control group were iv administered with Fasudil Hydrochloride Injection, 60 mg added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Alprostadil Injection, 20 μg added into normal saline 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the changes of NISS scores, PTX-3, and carotid atherosclerotic plaque in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.3% and 93.8%, respectively, and there was difference between two groups (P<0.05). After treatment, the NISS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the NISS score in the treatment group were significantly lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the PTX-3 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the PTX-3 in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the plaque formation rate in the control and treatment groups were 35.4% and 56.8%, respectively, and the proportion of stable plaques were 52.0% and 94.1%, respectively, and there was difference between two groups (P<0.05). Conclusion Alprostadil has clinical curative effect in treatment of acute cerebral infarction, and improve clinical symptoms, decrease PTX-3, increase plaque stability, with good safety, which has a certain clinical application value.