目的 對4-甲磺?；揭宜岬暮铣晒に囘M(jìn)行改進(jìn)，使其更利于工業(yè)化生產(chǎn)。方法 以4-甲磺?；揭彝獮槠鹗荚?，在硅膠固載氟硼酸（HBF₄·SiO₂）的催化下，合成2-（4-（甲磺?；┍交?1-嗎啉代乙硫醇，再經(jīng)水解得到4-甲磺?；揭宜帷?b>結(jié)果 制得的4-甲磺?；揭宜豳|(zhì)量分?jǐn)?shù)為99.8%，總收率約75%。結(jié)論 改進(jìn)后的工藝原料便宜易得，反應(yīng)溫度低，時間短，操作簡單，更適用于4-甲磺酰基苯乙酸工業(yè)化生產(chǎn)。

Objective To study the improved method for synthesis of 4-methylsulphonylbenzoic acid, so as to provide more suitable technology for industrial production. Methods 4-Methyl sulfonyl acetophenone was used as starting material to synthesize 2-(4-(methylsulfonyl) phenyl)-1-morpholinoethanethione by the catalysis of HBF₄·SiO₂ (fluoroboricacid was supported on SiO₂), and 4-methylsulphonyl-benzoic acid was obtained by hydrolysis reaction. Results The target compound was synthesized. The purity of 4-methylsulphonylbenzoic acid was 99.8% and the total yield was 75%. Conclusion The improved method of synthesis has the advantages of low material cost, short reaction time, low reaction temperature, and simple operation, and is suitable for industrial production of 4-methylsulphonylbenzoic acid.