max）為33.34 mg/kg，最大效應(yīng)（Emax）即腦梗死率最小為3.02%。七十味珍珠丸對大鼠神經(jīng)行為學(xué)異常、體質(zhì)量無影響。七十味珍珠丸0.52、1.04、2.08、4.17、33.34 mg/kg組血清丙二醛（MDA）水平明顯降低（P<0.05）。七十味珍珠丸33.34、66.68、133.36 mg/kg組血清中超氧化物歧化酶（SOD）活力明顯升高（P<0.01、0.05）。結(jié)論 七十味珍珠丸能降低大鼠腦梗死率，有效劑量4.17~133.36 mg/kg，最大有效劑量33.34 mg/kg，可能與降低MDA水平，升高SOD活力有關(guān)。;Objective To reveal the dose-effect relationship of Qishiwei Zhenzhu Pills in treatment of cerebral ischemic-reperfusion injury in rats. Methods Cerebral ischemic-reperfusion injury model in rat was established. Qishiwei Zhenzhu Pills (3 mg/mL suspended in normal saline) were ig administered after model established. Then cerebral infarction rate, nerve behavior, body weight, and blood biochemical indexes were tested at 2 and 24 h, respectively. And an analysis of dose-effect relationship between dose and rate of cerebral infarction was carried out. Results Cerebral infarction rates in Qishiwei Zhenzhu Pills group (4.17, 8.33, 16.67, 33.34, 66.68, and 133.36 mg/kg) were obviously reduced (P<0.01, 0.05), and there was a clear negative correlation between dose and rate of cerebral infarction (P<0.05), and the correlation coefficient was -0.689. Qishiwei Zhenzhu Pills reached its Dmax of 33.34 mg/kg with Emax ie minimum rate of cerebral infarction 3.02%. There was no significant effect for Qishiwei Zhenzhu Pills on nerve behavior and body weight in rats. MDA contents in Qishiwei Zhenzhu Pills group (0.52, 1.04, 2.08, 4.17, and 33.34 mg/kg) were decreased (P<0.05), but total SOD activities in Qishiwei Zhenzhu Pills group (33.34, 66.68, and 133.36 mg/kg) were increased (P<0.01, 0.05). Conclusion Qishiwei Zhenzhu Pills can reduce the rate of cerebral infarction, and the effective dose range was from 4.17 to 133.36 mg/kg with its maximum effective dose of 33.34 mg/kg, which may be related to MDA content and SOD activity."/>

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首頁 > 過刊瀏覽>2017年第32卷第1期 >2017,32(1):10-15. DOI:10.7501/j.issn.1674-5515.2017.01.003
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七十味珍珠丸抗大鼠腦缺血再灌注損傷的量效關(guān)系研究

Dose-effect relationship of Qishiwei Zhenzhu Pills against cerebral ischemic-reperfusion injury in rats

發(fā)布日期：2017-01-21
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    [關(guān)鍵詞]
    [摘要]
    目的 揭示七十味珍珠丸抗大鼠腦缺血再灌注損傷的量效關(guān)系。方法 制備大鼠腦缺血再灌注損傷模型，七十味珍珠丸用生理鹽水配制成3 mg/mL混懸液，造模后立即ig給藥，于腦缺血2、24 h分別檢測大鼠腦梗死率、神經(jīng)行為學(xué)、體質(zhì)量和血液生化指標(biāo)，并分析給藥劑量與腦梗死率之間的量效關(guān)系。結(jié)果 七十味珍珠丸4.17、8.33、16.67、33.34、66.68、133.36 mg/kg組大鼠腦梗死率明顯降低（P<0.01、0.05），且與藥物劑量呈負(fù)相關(guān)（P<0.05，相關(guān)系數(shù)為-0.689），達(dá)峰劑量（Dmax）為33.34 mg/kg，最大效應(yīng)（Emax）即腦梗死率最小為3.02%。七十味珍珠丸對大鼠神經(jīng)行為學(xué)異常、體質(zhì)量無影響。七十味珍珠丸0.52、1.04、2.08、4.17、33.34 mg/kg組血清丙二醛（MDA）水平明顯降低（P<0.05）。七十味珍珠丸33.34、66.68、133.36 mg/kg組血清中超氧化物歧化酶（SOD）活力明顯升高（P<0.01、0.05）。結(jié)論 七十味珍珠丸能降低大鼠腦梗死率，有效劑量4.17~133.36 mg/kg，最大有效劑量33.34 mg/kg，可能與降低MDA水平，升高SOD活力有關(guān)。
    [Key word]
    [Abstract]
    Objective To reveal the dose-effect relationship of Qishiwei Zhenzhu Pills in treatment of cerebral ischemic-reperfusion injury in rats. Methods Cerebral ischemic-reperfusion injury model in rat was established. Qishiwei Zhenzhu Pills (3 mg/mL suspended in normal saline) were ig administered after model established. Then cerebral infarction rate, nerve behavior, body weight, and blood biochemical indexes were tested at 2 and 24 h, respectively. And an analysis of dose-effect relationship between dose and rate of cerebral infarction was carried out. Results Cerebral infarction rates in Qishiwei Zhenzhu Pills group (4.17, 8.33, 16.67, 33.34, 66.68, and 133.36 mg/kg) were obviously reduced (P<0.01, 0.05), and there was a clear negative correlation between dose and rate of cerebral infarction (P<0.05), and the correlation coefficient was -0.689. Qishiwei Zhenzhu Pills reached its Dmax of 33.34 mg/kg with Emax ie minimum rate of cerebral infarction 3.02%. There was no significant effect for Qishiwei Zhenzhu Pills on nerve behavior and body weight in rats. MDA contents in Qishiwei Zhenzhu Pills group (0.52, 1.04, 2.08, 4.17, and 33.34 mg/kg) were decreased (P<0.05), but total SOD activities in Qishiwei Zhenzhu Pills group (33.34, 66.68, and 133.36 mg/kg) were increased (P<0.01, 0.05). Conclusion Qishiwei Zhenzhu Pills can reduce the rate of cerebral infarction, and the effective dose range was from 4.17 to 133.36 mg/kg with its maximum effective dose of 33.34 mg/kg, which may be related to MDA content and SOD activity.
    [中圖分類號]
    [基金項目]
    中國博士后科學(xué)基金面上資助項目（2012M511916）；四川省中醫(yī)藥管理局科技專項（2012-E-040）；成都中醫(yī)藥大學(xué)自然科學(xué)青年教師創(chuàng)新基金項目（ZRQN1544）