目的 探討木丹顆粒聯(lián)合前列地爾注射液治療糖尿病足的臨床療效。方法 選取2015年7月-2016年7月在自貢市第四人民醫(yī)院進行治療的糖尿病足患者82例，根據(jù)治療方案的差別分為對照組（41例）和治療組（41例）。對照組靜脈滴注前列地爾注射液，20 μg加入生理鹽水250 mL，1次/d。治療組在對照組的基礎(chǔ)上口服木丹顆粒，1袋/次，3次/d。兩組患者均連續(xù)治療4周。觀察兩組患者臨床療效，同時比較兩組患者治療前后臨床癥狀評分、空腹血糖（FBG）和糖化血紅蛋白（HbA1c）水平、血清細(xì)胞因子及踝臂指數(shù)（ABI）和足趾皮膚溫度變化。結(jié)果 治療后，對照組和治療組總有效率分別為80.49%和95.12%，兩組總有效率比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組臨床癥狀評分均明顯降低，同組治療前后差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組的臨床癥狀評分降低程度優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組高敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-6（IL-6）、降鈣素原（PCT）、晚期糖基化終末化產(chǎn)物（AEGs）均降低，而血管內(nèi)皮生長因子（VEGF）、血小板源性生長因子（PDGF）水平均升高（P<0.05）；且治療組上述指標(biāo)改善更顯著（P<0.05）。兩組ABI和足趾皮膚溫度均升高，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組升高程度優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 木丹顆粒聯(lián)合前列地爾注射液治療糖尿病足療效顯著，可明顯改善患者臨床癥狀，降低血清炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Mudan Granules combined with Alprostadil Injection in treatment of diabetic foot. Methods Patients (82 cases) with diabetic foot in the Fourth People's Hospital of Zigong from July 2015 to July 2016 were divided into control group (41 cases) and treatment group (41 cases) based on different treatments. Patients in the control group were iv administered with Alprostadil Injection, 20 μg added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Mudan Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and clinical symptoms score, FBG, HbA1c, serum inflammatory factors, ABI, and toe skin temperature in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.49% and 95.12%, respectively, and there were differences between two groups (P<0.05). After treatment, clinical symptoms scores in two groups was significantly decreased (P<0.05). And the decrease degree in the treatment group was significantly better than those in the control group (P<0.05). The levels of hs-CRP, IL-6, PCT, and AEGs in two groups were significantly decreased, while VEGF and PDGF increased (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group (P<0.05). ABI and toe skin temperature in two groups were significantly increased (P<0.05). And the increase degree of ABI and toe skin temperature in the treatment group was more significant than that in the control group (P<0.05). Conclusion Mudan Granules combined with Alprostadil Injection has a significant clinical effect in treatment of diabetic foot, can improve clinical symptoms and decrease serum inflammatory response, which has a certain clinical application value.