目的 探討尼美舒利聯(lián)合雙醋瑞因治療膝骨性關(guān)節(jié)炎的臨床療效。方法 選取2015年8月-2016年8月在河南科技大學(xué)第一附屬醫(yī)院接受治療的膝骨性關(guān)節(jié)炎患者86例，按照治療方法的差別分為對(duì)照組和治療組，每組各43例。對(duì)照組口服雙醋瑞因膠囊，1粒/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服尼美舒利膠囊，1粒/次，2次/d。兩組患者均治療4周。觀察兩組的臨床療效，比較骨關(guān)節(jié)炎指數(shù)（WOMAC）評(píng)分、視覺(jué)模擬量表（VAS）評(píng)分、膝關(guān)節(jié)評(píng)分量表（LKSS）評(píng)分、白細(xì)胞介素-1（IL-1）、白細(xì)胞介素-6（IL-6）、環(huán)氧合酶-2（COX-2）和基質(zhì)金屬蛋白酶-3（MMP-3）的情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為81.40%、97.67%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組WOMAC評(píng)分和VAS評(píng)分均顯著降低，而LKSS評(píng)分均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組IL-1、IL-6、COX-2和MMP-3水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 尼美舒利聯(lián)合雙醋瑞因治療膝骨性關(guān)節(jié)炎具有較好的臨床療效，可改善臨床癥狀，降低炎性反應(yīng)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To evaluate the clinical effect of nimesulide combined with diacerein in treatment of knee osteoarthritis. Methods Patients (86 cases) with knee osteoarthritis in the First Affiliated Hospital of Henan University of Science & Technology from January 2015 to August 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Diacerein Capsules, 1 grain/time, once daily. Patients in the treatment group were po administered with Nimesulide Capsules on the basis of the control group, 1 grain/time, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and WOMAC score, VAS score, LKSS score, IL-1, IL-6, COX-2, and MMP-3 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 97.67%, respectively, and there was difference between two groups (P<0.05). After treatment, WOMAC scores and VAS scores in two groups were significantly decreased, but the LKSS scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IL-1, IL-6, COX-2, and MMP-3 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Nimesulide combined with diacerein has clinical curative effect in treatment of knee osteoarthritis, can improve clinical symptoms, and decrease inflammatory response, which has a certain clinical application value.