目的 研究地奧司明聯(lián)合舒洛地特治療下肢深靜脈血栓的效果。方法 選擇2014年1月-2016年6月在鞍山市中心醫(yī)院就診的下肢深靜脈血栓患者80例，隨機(jī)分為對(duì)照組和治療組，每組各40例。對(duì)照組口服舒洛地特軟膠囊，250 LSU/次，2次/d，治療組在對(duì)照組基礎(chǔ)上口服地奧司明片，1片/次，2次/d。兩組患者均治療3個(gè)月。觀察兩組的臨床療效，比較兩組動(dòng)脈血流指標(biāo)、VAS評(píng)分、行走功能的情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為72.50%、90.00%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血流速度和搏動(dòng)指數(shù)均顯著提高，而阻力指數(shù)顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組VAS評(píng)分均顯著下降，而無(wú)痛行走距離和最大行走距離均顯著增加，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 地奧司明聯(lián)合舒洛地特治療下肢深靜脈血栓具有較好的臨床療效，能改善臨床癥狀，調(diào)節(jié)動(dòng)脈血流指標(biāo)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To study the clinical effect of diosmin combined with sulodexide in treatment of lower extremity deep venous thrombosis. Methods Patients (80 cases) with lower extremity deep venous thrombosis in Anshan Central Hospital from January 2014 to June 2016 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Sulodexide Soft Capsules, 250 LSU/time, twice daily. Patients in the treatment group were po administered with Diosmin Tables on the basis of the control group, 1 tablet/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and arterial blood flow indexes, VAS scores, and walking function in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 72.50% and 90.00%, respectively, and there was difference between two groups (P<0.05). After treatment, blood flow velocity and pulsation index in two groups were significantly increased, but the resistance index in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, VAS scores in two groups were significantly decreased, but painless walking distance and maximum walking distance in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Diosmin combined with sulodexide has clinical curative effect in treatment of lower extremity deep venous thrombosis, can improve clinical symptoms, and regulate arterial blood flow index, which has a certain clinical application value.