目的 探討葆宮止血顆粒聯(lián)合去氧孕烯炔雌醇治療功能失調(diào)性子宮出血的臨床療效。方法 選取2015年3月-2016年1月在鄭州大學(xué)第五附屬醫(yī)院接受治療的功能失調(diào)性子宮出血患者84例，隨機(jī)分為對(duì)照組（42例）和治療組（42例）。對(duì)照組患者口服去氧孕烯炔雌醇片，據(jù)陰道流血量的不同，給予不同的用藥量，出血量較多者口服去氧孕烯炔雌醇1片/次，每隔8小時(shí)一次；出血量較少者1片/次，每12小時(shí)1次；血止后繼續(xù)服用3 d后，漸減量至1片/次，1次/d。治療組在對(duì)照組的基礎(chǔ)上口服葆宮止血顆粒，1袋/次，3次/d。兩組患者均治療3個(gè)月經(jīng)周期。治療后，觀察兩組的臨床療效，比較兩組子宮內(nèi)膜厚度、出血控制時(shí)間、完全止血時(shí)間和性激素水平的變化。結(jié)果 治療后，兩組的總有效率分別為80.95%、97.62%，兩組總有效率比較具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組子宮內(nèi)膜厚度、出血控制時(shí)間、完全止血時(shí)間均顯著小于對(duì)照組（P<0.05）。兩組患者血清E₂、P、FSH和PRL水平顯著降低，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），且治療組上述指標(biāo)改善更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 葆宮止血顆粒聯(lián)合去氧孕烯炔雌醇治療功能失調(diào)性子宮出血效果顯著，可明顯改善患者臨床癥狀和性激素水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical curative effect of Gongbao Zhixue Granules combined with desogestrel ethinylestradiol in treatment of dysfunctional uterine bleeding. Methods Patients (84 cases) with dysfunctional uterine bleeding in The Fifth Affiliated Hospital of Zhengzhou University from March 2015 to January 2016 were randomly divided into control group (42 cases) and treatment group (42 cases). Patients in the control group were po administered with Desogestrel and Ethinylestradiol Tablets. Different dosage was given based different vaginal bleeding amount. Patients with more vaginal bleeding amount were po administered with Desogestrel and Ethinylestradiol Tablets, 1 tablet/time, once every 8 h. Patients with less vaginal bleeding amount were po administered with Desogestrel and Ethinylestradiol Tablets, 1 tablet/time, once every 12 h. Desogestrel and Ethinylestradiol Tablets were continued for 3 d after the bleeding stopped. And the dosage was decreased to 1 tablet/time, once daily. Patients in the treatment group were po administered with Gongbao Zhixue Granules, 1 bag/time, three times daily. Patients in two groups were treated for 3 menstrual cycles. After treatment, the clinical efficacy was evaluated, and endometrial thickness, bleeding control time, and complete hemostasis time, and sex hormone levels were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.95%and 97.62%, respectively, and there were differences between two groups (P<0.05). The endometrial thickness, bleeding control time, and complete hemostasis time were lower than those in the treatment group with significantly differences (P<0.05). E₂, P, FSH, and PRL levels in two groups were decreased significantly (P<0.05). And those indexes in the treatment group decreased more significantly than those in the control group (P<0.05). Conclusion Gongbao Zhixue Granules combined with desogestrel ethinylestradiol has a significant clinical effect in treatment of dysfunctional uterine bleeding, and can significantly improve the clinical symptoms and sex hormone levels, which has a certain clinical application value.