目的 總結(jié)淮安市第二人民醫(yī)院2014-2015年抗腫瘤藥物不良反應(yīng)發(fā)生的情況，分析其發(fā)生的原因及其藥物種類，指導(dǎo)臨床醫(yī)生合理、安全、規(guī)范的使用藥物。方法 統(tǒng)計(jì)分析淮安市第二人民醫(yī)院2014年1月-2015年12月上報(bào)國(guó)家藥品不良反應(yīng)監(jiān)測(cè)中心藥物不良反應(yīng)發(fā)生的情況，尋找容易發(fā)生藥物不良反應(yīng)的各種狀況，并制定相應(yīng)的對(duì)策。結(jié)果 186例藥物不良反應(yīng)報(bào)告中，患者年齡5~86歲，60歲以上老年患者發(fā)生藥物不良反應(yīng)最多，占53.77%；共涉及抗腫瘤藥物6類31個(gè)品種；引起血液系統(tǒng)、消化系統(tǒng)不良反應(yīng)最多，其次為皮膚及其附件；靜脈滴注引起藥物不良反應(yīng)最多；藥物不良反應(yīng)主要來自藥劑師的報(bào)告。結(jié)論 臨床應(yīng)加強(qiáng)對(duì)抗腫瘤藥不良反應(yīng)的監(jiān)測(cè)工作，及時(shí)發(fā)現(xiàn)、報(bào)告，為臨床安全用藥提供參考依據(jù)，減少或避免藥物不良反應(yīng)對(duì)患者生活質(zhì)量的影響。

Objective To summarize adverse drug reactions induced by antitumor drugs in the Second People's Hospital of Huaian from 2014 to 2015, and analyze its reasons and types of drugs in order to guide clinical physicians use of drugs reasonably, safely, and standardly. Methods Adverse drug reaction cases collected in the Second People's Hospital of Huaian from January 2014 to December 2015 by National Center for ADR Monitoring were statistically analyzed in order to find adverse drug reaction in various situations which were likely to happen and make corresponding countermeasures. Results Ages of patients were from 5 to 86 in 186 cases. The highest incidence occurred in patients of above 60 years, accounting for 53.77%. All the cases were involved 6 categories and 31 varieties. Adverse drug reaction was mainly related to the hematologic system and digestive system, followed by the skin and accessories. Intravenous dripping was used as the main way of infusion. Adverse drug reaction was mainly reported by pharmacists. Conclusion It is important to pay close attention to the adverse drug reaction induced by antitumor drugs. Adverse drug reaction should be discovered and reported in time, which may provide a reference for the clinical use and lessen or avoid the occurrence of adverse drug reaction and improve the life quality of patients.