目的 分析吉林大學(xué)中日聯(lián)誼醫(yī)院特殊使用級抗菌藥物的應(yīng)用情況，為臨床合理使用和管理此類藥物提供參考。方法 運用回顧性調(diào)查方法，收集吉林大學(xué)中日聯(lián)誼醫(yī)院2011-2015年特殊使用級抗菌藥物的應(yīng)用數(shù)據(jù)，對藥物的名稱、規(guī)格、使用數(shù)量、銷售金額、用藥頻度（DDDs）、日均費用（DDC）進(jìn)行統(tǒng)計分析。結(jié)果 特殊使用級抗菌藥物品種數(shù)、品規(guī)數(shù)保持基本穩(wěn)定，銷售金額排序前兩位的分別是2011年的頭孢菌素類和碳青霉烯類、2012-2015年的碳青霉烯類和單環(huán)類，DDDs分別為167 200、121 321、92 586、90 029、88 302，DDC值呈逐年下降趨勢。結(jié)論 吉林大學(xué)中日聯(lián)誼醫(yī)院特殊使用級抗菌藥物的使用基本合理，銷售金額、用藥頻度、日均費用等指標(biāo)整體下降，提示通過醫(yī)院加強管理和藥師的積極參與，抗菌藥物臨床應(yīng)用專項整治活動取得成效。

Objective To analyze the application of antibacterial agents in special use level in China-Japan Union Hospital of Jilin University, and provide a reference for clinical rational use and management of these drugs. Methods Retrospective investigation method was used, and antibacterial agents in special use level application data from 2011 to 2015 were collected. Name, specifications, use quantity, sales amount, frequency (DDDs), and average daily cost (DDC) were analyzed. Results Varieties and specifications remained basically stable. Sales ranked the top two were cephalosporins and carbon alkene drugs (in 2011) and carbon alkene classes and class ring drugs (from 2012 to 2015), and DDDs were 167 200, 121 321, 92 586, 121 321, and 92 586, respectively. DDC values declined year by year. Conclusion Use of antibacterial agents in special use level in China-Japan Union Hospital of Jilin University from 2011 to 2015 is rational. Sales amount, frequency, and average daily cost indicators decline year by year. It is suggested that hospital management and pharmacist's active participation should be strengthened, and achieve better results of clinical application of antibacterial drugs special rectification activities.