目的 探討雙黃連顆粒聯(lián)合阿莫西林克拉維酸鉀治療小兒肺炎的臨床療效。方法 選取2015年8月-2016年8月在駐馬店市中心醫(yī)院進(jìn)行治療的小兒肺炎患者86例，根據(jù)治療方案的差別分為對照組和治療組，每組各43例。對照組靜脈滴注注射用阿莫西林克拉維酸鉀，30 mg/kg加入生理鹽水100 mL中，2次/d。治療組在對照組的基礎(chǔ)上口服雙黃連顆粒，3~8歲患兒1袋/次；>8歲患兒2袋/次，3次/d。兩組患兒均連續(xù)治療2周。觀察兩組患者臨床療效，同時比較兩組治療前后臨床癥狀消失時間和血清學(xué)指標(biāo)變化。結(jié)果 治療后，對照組和治療組總有效率分別為81.40%和95.35%，兩組總有效率比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組患兒退熱、咳嗽、肺部啰音和扁桃體及咽部充血等消失時間均明顯短于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者血清超敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、降鈣素原（PCT）和可溶性髓系細(xì)胞觸發(fā)受體-1（sTREM-1）水平明顯低于同組治療前，同組治療前后差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療后治療組比對照組降低的更加顯著，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 雙黃連顆粒聯(lián)合阿莫西林克拉維酸鉀治療小兒肺炎效果顯著，可促進(jìn)患兒臨床癥狀改善，并能降低機(jī)體炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Shuanghuanglian Granules combined with amoxicillin and potassium in treatment of children with pneumonia. Methods Children (86 cases) with pneumonia in Zhumadian Central Hospital from August 2015 to August 2016 were divided into control and treatment groups based on different treatments, and each group had 43 cases. Children in the control group were iv administered with Amoxicillin Sodium and Clavulanate Potassium for injection, 30 mg/kg added into normal saline 100 mL, twice daily. Children in the treatment group were po administered with Shuanghuanglian Granules on the basis of the control group, 1 bag/time for 3-8 years old children, 2 bag/time for >8 years old children, three times daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the disappearing time of clinical symptoms and serological index in two groups before and after treatment was compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 95.35%, respectively, and there was difference between two groups (P<0.05). After treatment, pyretolysis time, disappearing time of cough, pulmonary rales, tonsil and pharyngeal hyperemia in treatment group were significantly shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, hs-CRP, IL-6, TNF-α, PCT, and sTREM-1 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shuanghuanglian Granules combined with amoxicillin and potassium has a significant effect in treatment of children with pneumonia, can significantly improve clinical symptoms and reduce the inflammatory response, which has a certain clinical application value.