目的 探討單磷酸阿糖腺苷聯(lián)合布地奈德治療小兒毛細支氣管炎的臨床療效。方法 選取2014年9月-2016年9月沈陽醫(yī)學院附屬中心醫(yī)院兒科收治的毛細支氣管炎患者151例，隨機分成對照組（75例）和治療組（76例）。對照組霧化吸入吸入用布地奈德混懸液，0.5 mg加入生理鹽水3 mL，1次/d，10 min/次。治療組在對照組的基礎(chǔ)上靜脈滴注注射用單磷酸阿糖腺苷，0.1 g加入5%葡萄糖溶液100 mL中，1次/d。所有患者均治療1周。觀察兩組患者臨床效果，對比兩組治療前后癥狀消失時間、住院時間、炎性指標以及不良反應(yīng)情況。結(jié)果 治療后，對照組和治療組總有效率分別為84.00%和96.05%，兩組總有效率比較差異具有統(tǒng)計學意義（P<0.05）。治療后，治療組患兒的退熱時間、濕啰音消失時間、喘息消失時間和咳嗽消失時間以及住院時間均明顯短于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患兒腫瘤壞死因子-α（TNF-α）、白細胞介素-6（IL-6）以及IL-8指標均明顯降低（P<0.05）；且治療組的降低程度明顯優(yōu)于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05）。結(jié)論 單磷酸阿糖腺苷聯(lián)合布地奈德治療小兒毛細支氣管炎，在臨床癥狀消失時間、住院時間以及炎癥因子水平改善方面上均優(yōu)于單獨使用布地奈德治療，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of clinical study on vidarabine monophosphate combined with budesonide in treatment of children with bronchiolitis. Methods Children (151 cases) with bronchiolitis in Central Hospital Affiliated to Shenyang Medical College from September 2014 to September 2016 were divided into control group (75 cases) and treatment group (76 cases). Children in the control group were aerosol inhalation administered with Budesonide Suspension for inhalation, 0.5 mg added into normal saline 3 mL, once daily, 10 min/time. Patients in the treatment group were iv administered with Vidarabine Monophosphate for injection on the basis of the control group, 0.1 g added into 5% glucose solution 100 mL, once daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, symptom disappearance time, hospitalization time, inflammatory indexes, and incidence of adverse reactions in two groups before and after treatment was compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.00% and 96.05%, respectively, and there was difference between two groups (P<0.05). After treatment, pyretolysis time, the disappearance time of lung wet rales, wheezing, and cough, and hospitalization time in treatment group were significantly shorter than those in the control group, with significant difference between two groups (P<0.05). After treatment, TNF-α, IL-6, and IL-8 in two groups was significantly decreased (P<0.05). And the decrease degree of these indicators in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Adenosine monophosphate combined with budesonide has clinical curative effect in treatment of children with bronchiolitis, especially on the disappearance time of clinical symptoms, hospitalization time improvement, and inflammatory factor, which has a certain clinical application value.