目的 探究舒肝解郁膠囊聯(lián)合安非他酮片治療老年抑郁癥的臨床療效。方法 選取2013年6月-2016年6月于重慶三峽中心醫(yī)院平湖分院進行就診的老年抑郁癥患者120例，按隨機抽樣法分為對照組和治療組，每組各60例。對照組口服鹽酸安非他酮片，起始量75 mg/d，2周內(nèi)根據(jù)病情增加劑量，最大劑量為300 mg/d。治療組在對照組基礎上口服舒肝解郁膠囊，0.72 g/次，2次/d。兩組患者均治療8周。觀察兩組的臨床療效，比較兩組的漢密爾頓抑郁量表（HAMD）評分和漢密爾頓焦慮量表（HAMA）評分的情況。結(jié)果 治療后，對照組和治療組的總有效率分別為71.7%、85.0%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療4、6、8周后，兩組HAMD評分和HAMA評分均顯著下降，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療8周后，治療組觀察指標的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 舒肝解郁膠囊聯(lián)合安非他酮片治療老年抑郁癥具有較好的臨床療效，可改善臨床癥狀，安全性較好，具有一定的臨床推廣應用價值。

Objective To explore the clinical effect of Shugan Jieyu Capsules combined with Bupropion Hydrochloride Tablets in treatment of senile depression. Methods Patients (120 cases) with senile depression in Pinghu Branch of Chongqing Three Gorges Central Hospital from June 2013 to June 2016 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Bupropion Hydrochloride Tablets, starting dosage was 75 mg/d, increased the dose according to the condition within 2 weeks, and maximum dosage was 300 mg/d. Patients in the treatment group were po administered with Shugan Jieyu Capsules on the basis of the control group, 0.72 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and HAMD scores and HAMA scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.7% and 85.0%, respectively, and there was difference between two groups (P<0.05). After treatment for 4, 6, 8 weeks, HAMD scores and HAMA scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And after treatment for 8 weeks, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Shugan Jieyu Capsules combined with Bupropion Hydrochloride Tablets has effect in treatment of senile depression, can improve clinical symptoms with good safety, which has a certain clinical application value.