目的 研究胡桃楸Juglans mandshurica Maxim.莖枝含藥雞蛋（與胡桃楸莖枝同煮的雞蛋）對(duì)小鼠體內(nèi)H22肝癌實(shí)體瘤的抗腫瘤活性。方法 采用荷H22肝癌實(shí)體瘤小鼠模型，以腫瘤質(zhì)量、抑瘤率為指標(biāo)研究胡桃楸莖枝含藥雞蛋對(duì)腫瘤生長(zhǎng)的抑制作用，以免疫器官指數(shù)、外周血象為指標(biāo)考察對(duì)荷瘤機(jī)體生存質(zhì)量的影響。結(jié)果 胡桃楸莖枝含藥雞蛋在0.64、1.28、2.56 g/kg劑量下對(duì)小鼠肝癌H22實(shí)體瘤的生長(zhǎng)均有較好的抑制作用，呈一定的量效關(guān)系。實(shí)驗(yàn)結(jié)束時(shí)，對(duì)照組、模型組和各含藥雞蛋組小鼠的體質(zhì)量均增加。胡桃楸含藥雞蛋組胸腺指數(shù)、脾臟指數(shù)明顯升高，外周紅細(xì)胞數(shù)、血紅蛋白含量提高，總白細(xì)胞數(shù)降低。結(jié)論 胡桃楸莖枝含藥雞蛋對(duì)H22細(xì)胞具有較好的抗腫瘤作用。

Objective To evaluate the anti-tumor activity of the eggs decocted with branches of Juglans mandshurica against murine H22 hepatocarcinoma cell in mice. Methods Mice bearing H22 tumor models were set up. Tumor weight and inhibition ratio of tumor growth were obtained for the evaluation of the anti-tumor activity. And immune organ index and hematological parameters were determined to estimate the protective effects on these functions of H22 tumor bearing mouse. Results The eggs decocted with branches of J. mandshurica at dose of 0.64, 1.28, and 2.56 g/kg showed inhibitory effect on the growth of tumor tissues, in a dose-and time-dependent manner. Body weights of mice in control group, model group, and eggs decocted with branches of J. mandshurica group were increased after treatment. The thymus index and spleen index in eggs decocted with branches of J. mandshurica group were significantly increased, the number of peripheral red blood cells and hemoglobin were improved, but the numbers of white blood cells were decreased. Conclusion The eggs decocted with branches of J. mandshurica has good anti-tumor effect against H22 cell.

遼寧省自然科學(xué)基金資助項(xiàng)目（2015020711）；遼寧省高等學(xué)校杰出青年學(xué)者成長(zhǎng)計(jì)劃項(xiàng)目（LJQ2014099）；遼寧中醫(yī)藥大學(xué)杏林學(xué)者青藍(lán)工程項(xiàng)目（2015）