目的 探討馬來酸桂哌齊特聯(lián)合尤瑞克林治療急性腦梗死的臨床療效。方法 收集2015年10月-2016年10月在沈陽市第四人民醫(yī)院治療的急性腦梗死患者88例，根據(jù)治療方案的不同分為對照組（44例）和治療組（44例）。對照組患者靜脈滴注注射用尤瑞克林30 min，0.15 PNA單位加入100 mL生理鹽水中，1次/d。治療組患者在對照組的基礎(chǔ)上靜脈滴注馬來酸桂哌齊特注射液，8 mL加入10%葡萄糖注射液500 mL中，1次/d。兩組患者均連續(xù)治療2周。評價兩組患者臨床療效，分析比較兩組治療前后ADL評分、神經(jīng)功能缺損評分、血清學指標和血液流變學指標變化。結(jié)果 治療后，對照組和治療組的總有效率分別為81.82%、97.73%，兩組總有效率比較差異有統(tǒng)計學意義（P<0.05）。治療后，兩組ADL評分顯著升高，神經(jīng)功能缺損評分顯著降低，同組比較差異具有統(tǒng)計學意義（P<0.05）；且治療組上述評分改善更顯著（P<0.05）。治療后，兩組患者血清腫瘤壞死因子-α（TNF-α）、單核細胞趨化蛋白-1（MCP-1）、N末端B型腦鈉肽原（NT-proBNP）和可溶性細胞間黏附分子-1（sICAM-1）水平均明顯降低，而白細胞介素-10（IL-10）水平明顯增高，同組比較差異具有統(tǒng)計學意義（P<0.05）；且治療組上述血清學指標改善程度優(yōu)于對照組（P<0.05）。治療后，兩組患者纖維蛋白原、血漿黏度、全血低切黏度和全血高切黏度均顯著降低（P<0.05）；且治療后治療組患者比對照組降低更顯著（P<0.05）。結(jié)論 馬來酸桂哌齊特聯(lián)合尤瑞克林治療急性腦梗死的臨床效果顯著，可明顯改善患者神經(jīng)功能和日常生活能力，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of cinepazide maleate combined with urinary kallidinogenase in treatment of acute cerebral infarction. Methods Patients (88 cases) with acute cerebral infarction in Shenyang the Fourth Hospital of People from October 2015 to October 2016 were divided into control (44 cases) and treatment (44 cases) groups based on different treatments. Patients in the control group were iv administered with Urinary Kallidinogenase for injection for 30 min, 0.15 PNA added into 100 mL normal saline, once daily. Patients in the treatment group were iv administered with Cinepazide Maleate Injection on the basis of the control group, 8 mL added into 10% glucose injection 500 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and ADL and neurological deficit scores, serological indexes, and blood rheology indexes in two groups before and after treatment were analyzed and compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 97.73%, respectively, and there was difference between two groups (P<0.05). After treatment, ADL score in two groups was significantly increased, while neurological deficit score was significantly decreased, and the difference was statistically significant in the same group (P<0.05). The two scores in the treatment were improved more significantly than those in the control group, with significant difference between two groups (P<0.05). After treatment, TNF-α, MCP-1, NT-proBNP, and sICAM-1 levels in two groups were significantly decreased, and IL-10 level was significantly increased, and there was difference in the same group (P<0.05). And these serological indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, fibrinogen, plasma viscosity, whole blood low shear viscosity, and whole blood high shear viscosity in two groups were significantly decreased (P<0.05). And these blood rheology indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Cinepazide maleate combined with urinary kallidinogenase has a significant effect in treatment of acute cerebral infarction, and can significantly improve the neurological function and activity of daily living, which has a certain clinical application value.