目的 探究心腦寧膠囊聯(lián)合氯吡格雷治療不穩(wěn)定型心絞痛的臨床療效。方法 選取2015年1月-2016年7月在華中科技大學(xué)附屬協(xié)和醫(yī)院西院接受治療的不穩(wěn)定型心絞痛患者96例，隨機(jī)分成對(duì)照組和治療組，每組各48例。對(duì)照組口服硫酸氫氯吡格雷片，首劑量300 mg，1次/d，癥狀減輕后75 mg/次，1次/d。治療組在對(duì)照組的基礎(chǔ)上口服心腦寧膠囊，2～3粒/次，3次/d。兩組患者均連續(xù)治療8周。比較兩組患者治療前后臨床療效、心絞痛發(fā)作頻率和持續(xù)時(shí)間、硝酸甘油日耗量、血清超敏C-反應(yīng)蛋白（hs-CRP）和白介素-6（IL-6）水平。結(jié)果 治療后，對(duì)照組的總有效率為79.17%，顯著低于治療組的91.67%，兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者心絞痛發(fā)作頻率、持續(xù)時(shí)間和硝酸甘油的日消耗量均顯著下降，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者比對(duì)照組降低更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清hs-CRP和IL-6均顯著降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者上述指標(biāo)改善明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 心腦寧膠囊聯(lián)合氯吡格雷治療不穩(wěn)定型心絞痛能夠使患者心絞痛發(fā)作頻率和持續(xù)時(shí)間降低，同時(shí)可減少硝酸甘油日耗量，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the curative effect of Xinnaoning Capsules combined with clopidogrel in treatment of unstable angina pectoris. Methods Patients (96 cases) with unstable angina pectoris in the West Hospital of Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology from January 2015 to July 2016 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Clopidogrel Bisulfate Tablets, the first dosage was 300 mg, and 75 mg/time after symptom decreased, once daily. Patients in the treatment group were po administered with Xinnaoning Capsules on the basis of the control group, 2-3 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy, the frequency and duration of angina pectoris, nitroglycerin daily consumption, hs-CRP and IL-6 levels in two groups were compared. Results After treatment, the clinical efficacy in the control group was 79.17%, which was significantly lower than 91.67% in the treatment group, with significant difference between two groups (P<0.05). After treatment, the frequency and duration of angina pectoris, and nitroglycerin daily consumption in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators levels in the treatment group were decreased more significantly than those in the control group, with significant difference between two groups (P<0.05). After treatment, the serum hs-CRP and IL-6 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xinnaoning Capsules combined with clopidogrel can reduce the frequency and duration of angina pectoris in treatment of unstable angina pectoris with decreasing nitroglycerin daily consumption, which has a certain clinical application value.