目的 探討小兒智力糖漿聯(lián)合托吡酯治療兒童抽動(dòng)障礙的臨床療效。方法 選取2010年6月-2015年6月天津市第五中心醫(yī)院門診診治的兒童抽動(dòng)障礙患者168例，隨機(jī)分為對(duì)照組和治療組，每組各84例，對(duì)照組口服托吡酯片，起始劑量為0.5 mg/（kg·d），逐步增加劑量，一般維持在2～3 mg/（kg·d），分次口服，在癥狀完全停止后逐漸減量直至停用。治療組在對(duì)照組的基礎(chǔ)上口服小兒智力糖漿，10～15 mL/次，3次/d。兩組患者均治療2個(gè)月。觀察兩組的臨床療效，比較兩組耶魯綜合抽動(dòng)嚴(yán)重程度量表（YGTSS）評(píng)分、藥物的起效時(shí)間和不良反應(yīng)情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為84.5%、90.5%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療4、8周后，兩組患兒YGTSS評(píng)分均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組YGTSS評(píng)分降低更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療組的起效時(shí)間顯著短于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組患兒在治療過程中均未出現(xiàn)嚴(yán)重不良反應(yīng)，且兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 小兒智力糖漿聯(lián)合托吡酯治療兒童抽動(dòng)障礙具有較好的臨床療效，起效速度快，不良反應(yīng)少，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Xiaoer Zhili Syrup combined with topiramate in treatment of children with tic disorder. Methods Children (168 cases) with tic disorder in Tianjin Fifth Central Hospital from June 2010 to June 2015 were randomly divided into control and treatment groups, and each group had 84 cases. Patients in the control group were po administered with Topiramate Tablets. The initial dosage was 0.5 mg/(kg·d), and the dose was gradually increased, keeping at 2-3 mg/(kg·d) by several times of oral. The dose was gradually decreased until stopped after the symptoms disappeared completely. Patients in the treatment group were po administered with Xiaoer Zhili Syrup on the basis of the control group, 10-15 mL/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and YGTSS scores, onset time, and adverse reactions in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.5% and 90.5%, respectively, and there was difference between two groups (P<0.05). After treatment for 4 and 8 months, YGTSS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the scores in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). The onset time in treatment group was shorter than that in control group, and there was difference between two groups (P<0.05). There were no serious adverse reactions during the treatment, and there was no significant difference in adverse effects rate between two groups. Conclusion Xiaoer Zhili Syrup combined with topiramate has clinical curative effect in treatment of children with tic disorder, and can shorten onset time with less adverse reaction, which is worthy of clinical application.