目的 探討細辛腦注射液聯(lián)合鹽酸莫西沙星氯化鈉注射液治療成人支原體肺炎的臨床療效。方法 選取2015年9月-2016年9月在重慶市巴南區(qū)第二人民醫(yī)院進行治療的成人支原體肺炎患者88例，根據(jù)治療方案的差別分為對照組和治療組，每組各44例。對照組靜脈滴注鹽酸莫西沙星氯化鈉注射液，0.4 g/次，1次/d。治療組在對照組基礎(chǔ)上靜脈滴注注射用細辛腦，24 mg加入到5%葡萄糖溶液250 mL中，2次/d。兩組患者均治療2周。觀察兩組的臨床療效，比較臨床癥狀消失時間和血清學(xué)指標。結(jié)果 治療后，對照組和治療組的總有效率分別為81.82%、97.73%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組體溫恢復(fù)時間、咳嗽消失時間、肺部啰音消失時間均比對照組明顯縮短，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組血清白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、堿性成纖維細胞生長因子（bFGF）和降鈣素原（PCT）水平均顯著下降，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 細辛腦注射液聯(lián)合鹽酸莫西沙星氯化鈉注射液治療成人支原體肺炎具有較好的臨床療效，可明顯改善臨床癥狀，調(diào)節(jié)血清學(xué)指標，具有一定的臨床推廣應(yīng)用價值。

Objective To evaluate the clinical efficacy of Asarone for injection combined with Moxifloxacin Hydrochloride and Sodium Chloride Injection in treatment of mycoplasma pneumonia in adults. Methods Patients (88 cases) with mycoplasma pneumonia in Banan Second People's Hospital of Chongqing from September 2015 to September 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were iv administered with Moxifloxacin Hydrochloride and Sodium Chloride Injection, 0.4 g/time, once daily. Patients in the treatment group were iv administered with Asarone for injection on the basis of the control group, 24 mg added into 5% glucose solution 250 mL, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom disappearance time and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 97.73%, respectively, and there was difference between two groups (P<0.05). After treatment, the body temperature recovery time and the disappearance time of cough and pulmonary rales in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of IL-6, TNF-α, bFGF, and PCT in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Asarone for injection combined with Moxifloxacin Hydrochloride and Sodium Chloride Injection has clinical cutive effect in treatment of mycoplasma pneumonia in adults, can significantly improve clinical symptoms, and regulate serological indexes, which has a certain clinical application value.