目的 觀察卡絡(luò)磺鈉聯(lián)合西咪替丁治療上消化道出血的臨床療效。方法 選取2015年1月-2016年3月于湖北醫(yī)藥學(xué)院附屬東風(fēng)醫(yī)院接受治療的上消化道出血患者78例，隨機(jī)分為對(duì)照組和治療組，每組各39例。對(duì)照組給予西咪替丁注射液，取2 mL用5%葡萄糖注射液稀釋后靜脈推注，根據(jù)患者出血情況而定，最多每6小時(shí)靜推1次。治療組在對(duì)照組的治療基礎(chǔ)上加用注射用卡絡(luò)磺鈉，60～80 mg加入5%葡萄糖液稀釋后靜脈滴注，1次/d。兩組治療療程均為72 h。觀察兩組的臨床療效和止血效果，比較兩組治療前后血小板的變化情況。結(jié)果 治療后，對(duì)照組和治療組的臨床總有效率分別為82.05%、94.87%；兩組止血總有效率分別為89.74%、97.44%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療組的平均止血時(shí)間短于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組患者血小板水平明顯升高，高于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 卡絡(luò)磺鈉聯(lián)合西咪替丁治療上消化道出血具有較好的臨床療效，止血效果較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical efficacy of carbazochrome sodium sulfonate combined with cimitidine in treatment of upper gastrointestinal hemorrhage. Methods Patients (78 cases) with upper gastrointestinal hemorrhage in Dongfeng Hospital Affiliated to Hubei University of Medicine from January 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 39 cases. Patients in the control group were iv administered with Cimitidine Injcetion, 2 mL was diluted with 5% glucose injection. According to the hemorrhage, the patients were iv injected once every 6 h at most. Patients in the treatment group were iv administered with Carbazochrome Sodium Sulfonate for injection on the basis of the control group, and 60-80 mg was added into 5% glucose injection, once daily. Patients in two groups were treated for 72 h. After treatment, the clinical efficacy and hemostatic effect were evaluated, the changes of platelet in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.05% and 94.87%, respectively, hemostatic effects in two groups were 89.74% and 97.44%, and there were differences between two groups (P<0.05). The average hemostasis time in the treatment group was shorter than that in the control group, and there were differences between two groups (P<0.05). After treatment, the platelet level in the treatment group was increased significantly, and the platelet level in the treatment group was higher than that in the control group, and there were differences between two groups (P<0.05). Conclusion Carbazochrome sodium sulfonate combined with cimitidine has clinical curative effect in treatment of upper gastrointestinal hemorrhage, and hemostatic effect is better, which has a certain clinical application value.