目的 探討麝香保心丸聯(lián)合藻酸雙酯鈉治療不穩(wěn)定型心絞痛患者的臨床療效。方法 選取2014年2月-2016年2月天津醫(yī)科大學(xué)總醫(yī)院收治的不穩(wěn)定型心絞痛患者126例，隨機(jī)分為對照組和治療組，每組各63例。對照組靜脈滴注藻酸雙酯鈉注射液，0.1 g加入到生理鹽水500 mL，1次/d。治療組患者在對照組治療基礎(chǔ)上口服麝香保心丸，2丸/次，3次/d。兩組均連續(xù)治療15 d。觀察兩組患者的臨床療效和心電圖療效，同時(shí)比較兩組患者治療前后SAQ評分、心絞痛發(fā)作次數(shù)和心絞痛持續(xù)時(shí)間的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別為80.77%、98.08%；兩組心電圖總有效率分別為80.95%、96.83%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者SAQ評分均顯著升高，心絞痛發(fā)作次數(shù)和心絞痛持續(xù)時(shí)間均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組SAQ評分高于對照組，心絞痛發(fā)作次數(shù)和心絞痛持續(xù)時(shí)間低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 麝香保心丸聯(lián)合藻酸雙酯鈉治療不穩(wěn)定型心絞痛具有較好的臨床療效，可顯著降低心絞痛發(fā)作次數(shù)和持續(xù)時(shí)間，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical efficacy of Shexiang Baoxin Pills combined with alginic sodium diester in treatment of unstable angina. Methods Children (126 cases) with unstable angina in General Hospital of Tianjin Medical University from February 2014 to February 2016 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were iv administered with Alginic Sodium Diester Injection, 0.1 g added into normal saline 500 mL, once daily. Patients in the treatment group were po administered with Shexiang Baoxin Pills on the basis of the control group, 2 pills/time, three times daily. Patients in two groups were treated for 15 d. After treatment, the clinical efficacy and electrocardiogram efficacy were evaluated, and the changes of SAQ scores, frequency and duration of angina in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.77% and 98.08%, respectively, electrocardiogram efficacies in two groups were 80.95% and 96.83%, and there was difference between two groups (P < 0.05). After treatment, SAQ scores in two groups were significantly increased, but frequency and duration of angina were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, SAQ score in the treatment group was higher than that in the control group, frequency and duration of angina were lower than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Shexiang Baoxin Pills combined with alginic sodium diester has significant clinical efficacy in treatment of unstable angina, and can significantly reduce frequency and duration of angina, which has a certain clinical application value.