目的 探討百令膠囊聯(lián)合比阿培南治療肺氣腫的臨床效果。方法 收集2013年1月-2015年12月在河北大學(xué)附屬醫(yī)院接受治療的104例肺氣腫患者，隨機(jī)分為對(duì)照組和治療組，每組各52例。對(duì)照組患者靜脈滴注注射用比阿培南，0.6 g溶于100 mL生理鹽水，2次/d。治療組在對(duì)照組的基礎(chǔ)上口服百令膠囊，5~10粒/次，3次/d。兩組患者持續(xù)治療8周。治療后評(píng)價(jià)兩組患者臨床療效，同時(shí)比較分析兩組患者治療前后第1秒呼氣量（FEV₁）、用力肺活量（FVC）、肺活量（VC）、最大通氣量（MVV）、動(dòng)脈血?dú)怙柡投?、二氧化碳分壓?i>pCO₂）、氧分壓（pO₂）、動(dòng)脈氧分壓、氧合指數(shù)、細(xì)菌清除率和血清C反應(yīng)蛋白（CRP）改變。結(jié)果 治療后，對(duì)照組的有效率為78.85%，顯著低于治療組的88.46%，兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者FEV₁、FVC、VC和MVV水平均顯著升高（P<0.05），且治療后治療組患者上述肺功能指標(biāo)升高的更顯著（P<0.05）。治療后，兩組氧合指數(shù)、pO₂、動(dòng)脈氧分壓、動(dòng)脈血?dú)怙柡投让黠@升高，pCO₂明顯下降，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療后治療組患者血?dú)庵笜?biāo)結(jié)果明顯優(yōu)于對(duì)照組，兩組治療后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組細(xì)菌清除率明顯高于對(duì)照組，且治療組血清CRP含量明顯比對(duì)照組低，兩組細(xì)菌清除效果和CRP比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 百令膠囊聯(lián)合比阿培南能夠明顯提高肺氣腫患者的治療效果，對(duì)于改善肺氣腫患者肺部功能、降低體內(nèi)炎癥水平具有重要作用。

Objective To explore the clinical effect of Bailing Capsules combined with biapenem in treatment of emphysema. Methods Patients (104 cases) with emphysema in Affiliated Hospital of Hebei University from January 2013 to December 2015 were randomly divided into control and treatment groups, and each group had 52 cases. Patients in the control group were iv administered with Biapenem for injection, 0.6 g added into normal saline 100 mL, twice daily. Patients in the treatment group were po administered with Bailing Capsules on the basis of the control group, 5 - 10 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the changes of FEV₁, FVC, VC, MVV, arterial blood gas saturation, pCO₂, pO₂, arterial oxygen pressure, oxygenation index, bacterial eradication rate, and CRP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control was 78.85%, which was significantly lower than 88.46% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the FEV₁, FVC, VC, and MVV levels in two groups were significantly increased (P < 0.05). And the pulmonary function indexes in the treatment group were increased more significantly than those in the control group (P < 0.05). After treatment, oxygenation index, pO₂, and arterial oxygen pressure in two groups were significantly increased, and pCO₂ of the treatment group was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The blood gas indexes in treatment group were significantly better than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the bacterial eradication rate in the treatment group was significantly higher than that in the control group, at the same time CRP in treatment group was significantly lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Bailing Capsules combined with imipenem can significantly improve the treatment effect of patients with emphysema, which has an important role of improving lung function and reducing inflammation level of patients with emphysema.