目的 探討參貝北瓜膏聯(lián)合孟魯司特鈉咀嚼片治療小兒哮喘的臨床療效。方法 選取2014年5月-2016年5月在天津市泰達(dá)醫(yī)院兒科接受治療的小兒哮喘患兒102例，所有患兒采用隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組各51例。對(duì)照組口服孟魯司特鈉咀嚼片，年齡<6歲：4 mg/次，年齡≥6歲：5 mg/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服參貝北瓜膏，8 g/次，3次/d。所有患者均治療14 d。觀察兩組的臨床療效，比較兩組的肺功能和血?dú)庵笜?biāo)。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為78.4%、94.1%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組1秒用力呼氣容積（FEV₁）、肺活量（FVC）、1秒用力呼氣量占肺活量的百分比（FEV₁/FVC%）和呼氣峰流速值（PEF）均明顯升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的升高程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血氧分壓（pO₂）和酸堿度（pH）值均明顯增高，而二氧化碳分壓（pCO₂）均明顯降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 參貝北瓜膏聯(lián)合孟魯司特鈉咀嚼片治療小兒哮喘具有較好的臨床療效，可改善肺部功能，調(diào)節(jié)血?dú)庵笜?biāo)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Shenbei Beigua Cream combined with Montelukast Sodium Chewable Tablets in treatment with children asthma. Methods Children (102 cases) with asthma in Department of Pediatrics of Tianjin TEDA Hospital from May 2014 to May 2016 were randomly divided into control and treatment groups, and each group had 51 cases. Patients in the control group were po administered with Montelukast Sodium Chewable Tablets, age < 6 years: 4 mg/time, age ≥ 6 years: 5 mg/time, once daily. Patients in the treatment group were po administered with Shenbei Beigua Cream on the basis of the control group, 8 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and pulmonary function and blood gas indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.4% and 94.1%, respectively, and there was difference between two groups (P < 0.05). After treatment, FEV, FVC, FEV₁/FVC, and PEF in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). After treatment, pO₂ and pH value in two groups were significantly increased, but the pCO₂ in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shenbei Beigua Cream combined with Montelukast Sodium Chewable Tablets has clinical curative effect in treatment of children asthma, and can improve pulmonary function and regulate blood gas indexes, which has a certain clinical application value.