目的 探討替勃龍片聯(lián)合雙唑泰泡騰片治療老年性陰道炎的臨床療效。方法 選取2016年1月-2016年7月在信陽市第四人民醫(yī)院接受診治的老年性陰道炎患者90例，所有患者根據(jù)用藥方案的不同分為對照組和治療組，每組各45例。對照組每晚清潔外陰后于陰道深處置入雙唑泰泡騰片，1片/次，1次/d。治療組在對照組基礎(chǔ)上口服替勃龍片，1片/次，1次/d。兩組患者均連續(xù)治療3個月。觀察兩組的臨床療效，比較兩組的臨床癥狀消失時間和生活質(zhì)量。結(jié)果 治療后，對照組和治療組的總有效率分別為77.78%、95.56%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組外陰瘙癢、陰道黏膜充血和陰道分泌物消失時間明顯短于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組軀體功能、心理功能、社會功能和物質(zhì)生活評分均明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的升高程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 替勃龍片聯(lián)合雙唑泰泡騰片治療老年性陰道炎具有較好的臨床療效，可縮短臨床癥狀消失時間，改善生活質(zhì)量，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Tibolone Tablets combined with Metronidazole Clotrimazole and Chlorhexidine Acetate Effervescent Tablets in treatment of senile vaginitis. Methods Patients (90 cases) with senile vaginitis in Xinyang Fourth People's Hospital from January 2016 to July 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 45 cases. Patients in the control group were placed with Metronidazole Clotrimazole and Chlorhexidine Acetate Effervescent Tablets into vagina deep at bedtime after cleaning the vulva, 1 tablet/time, once daily. Patients in the treatment group were po administered with Tibolone Tablets on the basis of the control group, 1 tablet/time, once daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and clinical symptoms disappearance time and quality of life in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.78% and 95.56%, respectively, and there was difference between two groups (P < 0.05). After treatment, the clinical symptoms disappearance time of genital itching, vaginal mucosal congestion, and vaginal secretions in the treatment group were shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the scores of physical function, psychological function, social function, and material life in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Tibolone Tablets combined with Metronidazole Clotrimazole and Chlorhexidine Acetate Effervescent Tablets has clinical curative effect in treatment of senile vaginitis, and shorten clinical symptoms disappearance time, and improve the quality of life, which has a certain clinical application value.