目的 探討氟比洛芬酯聯(lián)合舒芬太尼用于老年膝關(guān)節(jié)置換術(shù)后鎮(zhèn)痛作用的臨床療效。方法 選取2013年5月-2015年8月在河南省洛陽正骨醫(yī)院接受膝關(guān)節(jié)置換術(shù)患者150例，根據(jù)其術(shù)中麻醉方式不同分為對(duì)照組（85例）和治療組（65例）。對(duì)照組靜脈滴注枸櫞酸舒芬太尼注射液，0.04 μg/（kg·h）加入生理鹽水至100 mL。治療組靜脈滴注枸櫞酸舒芬太尼注射液和氟比洛芬酯注射液，枸櫞酸舒芬太尼注射液0.02 μg/（kg·h）與氟比洛芬酯注射液1.0 mg/kg加入生理鹽水至100 mL。觀察兩組的圍手術(shù)期血流動(dòng)力學(xué)、視覺模擬評(píng)分（VAS評(píng)分）、鎮(zhèn)靜評(píng)分（Ramsay評(píng)分）清醒時(shí)間和氣管插管拔管時(shí)間。結(jié)果 手術(shù)開始和手術(shù)后2 h，治療組收縮壓（SBP）、舒張壓（DBP）和平均動(dòng)脈壓（MAP）水平明顯高于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。術(shù)后4、12、24 h，治療組VAS評(píng)分低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組清醒時(shí)間和氣管插管拔管時(shí)間均長于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 氟比洛芬酯聯(lián)合舒芬太尼用于老年膝關(guān)節(jié)置換術(shù)后疼痛作用具有較好的臨床療效，能改圍手術(shù)期善血流動(dòng)力學(xué)，緩解疼痛，延長清醒時(shí)間和氣管插管拔管時(shí)間，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of flurbiprofen axetil combined with sufentanil in treatment of postoperative analgesia in elderly patients undergoing knee arthroplasty. Methods Elderly patients (150 cases) undergoing knee arthroplasty in Luoyang Bonesetting Hospital from May 2013 to August 2015 were enrolled in this study. According to the anesthesia method, patients were randomly divided into the control group (85 cases) and the treatment group (65 cases). Patients in the control group were iv administered with Sufentanil Citrate Injection, 0.04 μg/(kg·h) added into 100 mL normal saline. Patients in the treatment group were iv administered with Sufentanil Citrate Injection and Flurbiprofen Axetil Injection, and Sufentanil Citrate Injection 0.02μg/(kg·h) and Flurbiprofen Axetil Injection 1.0 mg/kg were added into normal saline to 100 mL. After treatment, perioperative hemodynamics, VAS scores, Ramsay scores, awake time and tracheal extubation time in two groups were compared. Results At the beginning of surgery and 2 h after surgery, SBP, DBP, and MAP in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P < 0.05). At 4, 8 and 8 h after surgery, the VAS scores in the treatment group were lower than that in the control group, and there was difference between two groups (P < 0.05). After treatment, awake time and tracheal extubation time in the treatment group were longer than those in the control group, and there was difference between two groups (P < 0.05). Conclusion Flurbiprofen axetil combined with sufentanil has clinical curative effect in treatment of postoperative analgesia in elderly patients undergoing knee arthroplasty, and can improve perioperative hemodynamics, relieve pain, and prolong awake time and tracheal extubation time, which has a certain clinical application value.