目的 探討心脈隆注射液聯(lián)合地高辛治療慢性充血性心力衰竭的臨床療效。方法 選取2016年2月—2017年2月在中國人民解放軍第四五四醫(yī)院進(jìn)行治療的慢性充血性心力衰竭患者88例，隨機(jī)分成對照組（44例）和治療組（44例）。對照組口服地高辛片，0.25 mg/次，1次/d。治療組在對照組的基礎(chǔ)上靜脈滴注心脈隆注射液，4 mL加入生理鹽水100 mL中，2次/d。兩組均連續(xù)治療2周。比較兩組患者治療前后臨床療效、紐約心臟病協(xié)會（NYHA）分級、心功能和血清學(xué)指標(biāo)變化。結(jié)果 治療后，對照組總有效率為79.55%，顯著低于治療組的95.45%，兩組比較差異具有統(tǒng)計學(xué)意義（P< 0.05）。治療后，對照組NYHA分級的Ⅰ級例數(shù)顯著低于治療組，且Ⅳ級患者顯著高于治療組，兩組患者NYHA分級比較差異具有統(tǒng)計學(xué)意義（P< 0.05）。治療后，兩組左心室舒張末期內(nèi)徑（LVEDD）、左心室收縮末期容積（LVESV）和左心室收縮末期內(nèi)徑（LVESD）水平顯著降低，左心室射血分?jǐn)?shù)（LVEE）和心指數(shù)（CI）指標(biāo)明顯升高，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P< 0.05）；且治療組患者心功能指標(biāo)顯著優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P< 0.05）。兩組血清N末端心房利鈉肽（NT-proBNP）和白細(xì)胞介素-6（IL-6）水平均顯著降低，血管內(nèi)皮生長因子（VEGF）顯著升高，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P< 0.05）；且治療組患者血清學(xué)指標(biāo)改善更顯著，兩組比較差異具有統(tǒng)計學(xué)意義（P< 0.05）。結(jié)論 心脈隆注射液聯(lián)合地高辛治療慢性充血性心力衰竭可明顯改善患者心功能，降低機(jī)體炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Xinmailong Injection combined with digoxin in treatment of chronic congestive heart failure. Methods Patients (88 cases) with chronic congestive heart failure in the NO. 454 Hospital of PLA from February 2016 to February 2017 were randomly divided into control (44 cases) and treatment (44 cases) groups. Patients in the control group were po administered with Digaoxin Tablets, 0.25 mg/time, once daily. Patients in the treatment group were iv administered with Xinmailong Injection on the basis of the control group, 4 mL added into normal saline 100 mL, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy, NYHA grade, cardiac function, and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 79.55%, which were significantly lower than 95.45% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the Ⅰ grade of NYHA in the control group was significantly lower than that in the treatment group, and Ⅳ grade in the control group was significantly higher than that in the treatment group, with significant difference between two groups (P < 0.05). After treatment, the LVEDD, LVESV, and LVESD levels in two groups significantly decreased, but CI and LVEE levels significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the cardiac function indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the NT-proBNP, ICAM-1, and IL-6 levels in two groups were significantly decreased, but VEGF level significantly increased, and there were differences in the same group (P < 0.05). And the improvement degree of the serological indexes in treatment group was more significantly than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Xinmailong Injection combined with digoxin has curative effect in treatment of chronic congestive heart failure can improve heart function and reduce the inflammation, which has a certain clinical application value.