目的 比較鹽酸右美托咪定注射液與枸櫞酸芬太尼注射液復(fù)合丙泊酚注射液用于無(wú)痛人流的麻醉效果。方法 選取2015年12月—2016年6月在天津醫(yī)科大學(xué)總醫(yī)院濱海醫(yī)院進(jìn)行無(wú)痛人流術(shù)的患者200例，按照麻醉方式的不同分為對(duì)照組（113例）和治療組（87例）。對(duì)照組靜脈泵注枸櫞酸芬太尼注射液，1 μg/kg稀釋至20 mL，泵注時(shí)間8 min。治療組靜脈泵注鹽酸右美托咪定注射液，0.5 μg/kg稀釋至20 mL，泵注時(shí)間8 min。而后兩組以1 mL/6 s靜脈注射丙泊酚注射液。觀察兩組麻醉效果，比較兩組的手術(shù)時(shí)間、蘇醒時(shí)間、丙泊酚用量、心率（HR）、平均動(dòng)脈壓（MAP）、血氧飽和度（SpO₂）和不良反應(yīng)。結(jié)果 治療后，對(duì)照組和治療組的麻醉的優(yōu)良率分別為74.34%、89.66%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P< 0.05）。在術(shù)中，治療組丙泊酚用量顯著低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P< 0.05）。在注射丙泊酚后（T2）、擴(kuò)宮時(shí)（T3）、刮宮時(shí)（T4）時(shí)，兩組HR和MAP水平明顯低于同組泵注右美托咪定或芬太尼后注射丙泊酚前（T1）時(shí)，同組比較差異有統(tǒng)計(jì)學(xué)意義（P< 0.05）；且在T3、T4時(shí)，治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。對(duì)照組和治療組的不良反應(yīng)發(fā)生率分別為32.74%、13.79%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P< 0.05）。結(jié)論 鹽酸右美托咪定注射液復(fù)合丙泊酚注射液用于無(wú)痛人流的麻醉效果優(yōu)于枸櫞酸芬太尼注射液復(fù)合丙泊酚注射液，可減少丙泊酚用量，改善術(shù)中HR和MAP水平，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To compare the effect of Dexmedetomidine Hydrochloride Injection and Fentanyl Citrate Injection combined with Propofol Injection for anaesthesia in painless abortion. Methods Patients (200 cases) in painless induced abortion in Binhai Hospital of General Hospital Affiliated to Tianjin Medical University from December 2015 to June 2016 were enrolled in this study. According to the difference anesthesia mode, patients were randomly divided into the control group (113 cases) and the treatment group (87 cases). Patients in the control group were intravenous pump injection administered with Fentanyl Citrate Injection, 1 μg/kg diluted to 20 mL, pump injection for 8 min. Patients in the treatment group were intravenous pump injection administered with Dexmedetomidine Hydrochloride Injection, 0.5 μg/kg diluted to 20 mL, pump injection for 8 min. Then patients in two groups were iv administered with Propofol Injection, infusion rate 1 mL/6 s. After treatment, the clinical efficacies were evaluated, and operation time, awakening time, propofol dosage, HR, MAP, SpO₂, and adverse reactions in two groups were compared. Results After treatment, the excellent rate of anesthesia in the control and treatment groups were 74.34% and 89.66%, respectively, and there was difference between two groups (P < 0.05). During the operation, the propofol dosage in the treatment group was significantly lower than that in the control group, and there was difference between two groups (P < 0.05). At T2, T3, and T4, the levels of HR and MAP in two groups were significantly lower than those at T1, and there were difference in the same group (P < 0.05). And at T3 and T4, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). The incidence of adverse reaction in the control and treatment groups were 32.74% and 13.79%, respectively, and there was difference between two groups (P < 0.05). Conclusion The anesthetic effect of Dexmedetomidine Hydrochloride Injection combined with Propofol Injection in painless induced abortion is better than that of Fentanyl Citrate Injection combined with Propofol Injection, can reduce propofol dosage, and improve the levels of HR and MAP, with good safety, which has a certain clinical application value.