30 min,連續(xù)用藥5 d后逐日遞減8 mg至第10天停藥。治療組鼓室注射注射用甲潑尼龍琥珀酸鈉,40 mg與稀釋液混合,1次/2 d,治療5次。觀察兩組的臨床療效,比較兩組的聽力平均閾值和并發(fā)癥療效。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為60.46%、83.72%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05)。治療后,兩組0.25、0.5、1、2、4、8 kHz的聽力平均閾值均顯著降低,同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05);且治療組這些觀察指標(biāo)明顯低于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05)。治療后,對(duì)照組和治療組耳鳴有效率分別為58.62%、83.87%,耳悶有效率分別為52.63%、83.34%,眩暈有效率分別為61.11%、89.47%,兩組并發(fā)癥有效率比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05)。結(jié)論 鼓室注射與靜脈滴注甲潑尼龍琥珀酸鈉治療突發(fā)性耳聾具有較好的療效,鼓室注射給藥在提高聽力閾值、治療并發(fā)癥方面優(yōu)于靜脈滴注給藥,安全性好,具有一定的臨床推廣應(yīng)用價(jià)值。;Objective To investigate the clinical effect of intratympanic injection and intravenous injection of methylprednisolone sodium succinate in treatment of sudden deafness. Methods Patients (86 cases) with sudden deafness in Rudong County People's Hospital from January 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 43 cases or 43 ears. Patients in the control group were iv administered with Methylprednisolone Sodium Succinate for injection, 0.8 mg/kg added into 5% glucose solution 250 mL, once daily, drip time >30 min, and after treatment for 5 d, decreased by 8 mg daily until the tenth day to stop drug. Patients in the treatment group were intratympanic injection administered with Methylprednisolone Sodium Succinate for injection, 40 mg mixed with dilute solution, once every 2 d, 5 times of treatment. After treatment, the clinical efficacies were evaluated, and average hearing threshold and efficacies of complication in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 60.46% and 83.72%, respectively, and there was difference between two groups (P < 0.05). After treatment, average hearing threshold of 0.25, 0.5, 1, 2, 4, and 8 kHz in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the efficacies of tinnitus, aural fullness, and vertigo in the control and treatment groups were 58.62% and 83.87%, 52.63% and 83.34%, and 61.11% and 89.47%, respectively, and there were difference between two groups (P < 0.05). Conclusion Intratympanic injection and intravenous injection of methylprednisolone sodium succinate has clinical curative effect in treatment of sudden deafness, the administration of intratympanic injection in increasing hearing threshold and treating complications was better than the administration of intravenous infusion, with good safety, which has a certain clinical application value."/>