目的 探討大蒜素膠囊聯(lián)合康復新液治療復發(fā)性口腔潰瘍的臨床療效。方法 選取2015年1月—2016年1月上海市嘉定區(qū)牙病防治所收治的復發(fā)性口腔潰瘍患者104例，采用隨機數(shù)字表法均分為對照組和治療組，每組各52例。對照組清水漱口后含漱康復新液，10 mL/次，30 min內(nèi)不進食和漱口，3次/d。治療組在對照組基礎上口服大蒜素膠囊，2粒/次，3次/d。兩組均治療3個月。觀察兩組的臨床療效，比較兩組的T淋巴細胞亞群、腫瘤壞死因子-α（TNF-α）、白細胞介素-6（IL-6）和視覺模擬量表（VAS）評分。結(jié)果 治療后，對照組和治療組的總有效率分別為76.92%、92.31%，兩組比較差異有統(tǒng)計學意義（P< 0.05）。治療后，兩組CD³⁺、CD⁴⁺和CD⁴⁺/CD⁸⁺水平均顯著升高，而CD⁸⁺水平均顯著下降，同組治療前后比較差異有統(tǒng)計學意義（P< 0.05）；且治療組這些觀察指標的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。治療后，兩組唾液TNF-α和IL-6水平均顯著降低，同組治療前后比較差異有統(tǒng)計學意義（P< 0.05）；且治療組這些觀察指標明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。治療后，兩組VAS評分均顯著降低，同組治療前后比較差異有統(tǒng)計學意義（P< 0.05）；且治療組VAS評分的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。結(jié)論 大蒜素膠囊聯(lián)合康復新液治療復發(fā)性口腔潰瘍具有較好的臨床療效，可改善臨床癥狀，提高機體免疫功能，降低炎性反應，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Garlicin Capsules combined with Kangfuxin Liquid in treatment of recurrent oral ulcer. Methods Patients (104 cases) with recurrent oral ulcer in Jading District Dental Prevention and Treatment Clinic of Shanghai from January 2015 to January 2016 were randomly divided into control and treatment groups according to random number table method, and each group had 52 cases. Patients in the control group were gargling administered with Kangfuxin Liquid after gargling with water, without eating or gargling within 30 min, 10 mL/time, three times daily. Patients in the treatment group were po administered with Garlicin Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and T lymphocyte subsets, TNF-α, IL-6, and VAS scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.92% and 92.31%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of CD³⁺, CD⁴⁺, and CD⁴⁺/CD⁸⁺ in two groups were significantly increased, but the levels of CD⁸⁺ in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TNF-α and IL-6 in saliva in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the VAS scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the VAS score in the treatment group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Garlicin Capsules combined with Kangfuxin Liquid has clinical curative effect in treatment of recurrent oral ulcer, can improve clinical symptoms, enhance immune function, and decrease inflammatory reaction, which has a certain clinical application value.