目的 探討天麻素片聯(lián)合奧拉西坦注射液治療腦外傷后綜合征的臨床療效。方法 選取2015年9月—2016年9月在深圳市寶安區(qū)中心醫(yī)院治療的腦外傷后綜合征患者78例，所有患者根據(jù)治療方案不同分為對照組和治療組，每組各39例。對照組靜脈滴注奧拉西坦注射液，4 g加入到5%葡萄糖注射液250 mL中，1次/d。治療組在對照組基礎(chǔ)上口服天麻素片，4片/次，3次/d。兩組患者均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的臨床癥狀積分和血清細胞因子水平。結(jié)果 治療后，對照組和治療組的總有效率分別為82.05%、97.44%，兩組比較差異有統(tǒng)計學(xué)意義（P< 0.05）。治療后，兩組頭痛、頭暈、焦慮、失眠、抑郁評分均明顯下降，同組治療前后比較差異有統(tǒng)計學(xué)意義（P< 0.05）；且治療組這些觀察指標(biāo)明顯低于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P< 0.05）。治療后，兩組血清白細胞介素-6（IL-6）、胰島素樣生長因子-1（IGF-1）、單核細胞趨化蛋白-1（MCP-1）、可溶性細胞黏附因子-1（sICAM-1）水平明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P< 0.05）；且治療組這些觀察指標(biāo)明顯低于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P< 0.05）。結(jié)論 天麻素片聯(lián)合奧拉西坦注射液治療腦外傷后綜合征具有較好的臨床療效，可明顯改善臨床癥狀，調(diào)節(jié)細胞因子水平，具有一定臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Gastrodin Tablets combined with Oxiracetam Injection in treatment of post-traumatic syndrome. Methods Patients (78 cases) with post-traumatic syndrome in Baoan District Central Hospital of Shenzhen from September 2015 to September 2016 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 39 cases. Patients in the control group were iv administered with Oxiracetam Injection, 4 g added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Gastrodin Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom scores and serum cytokine levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.05% and 97.44%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of headache, dizziness, anxiety, insomnia and depression in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of IL-6, IGF-1, MCP-1, and sICAM-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Gastrodin Tablets combined with Oxiracetam Injection has curative effect in treatment of post-traumatic syndrome, can obviously improve clinical symptoms, and regulate serum cytokine level, which has a certain clinical application value.