目的 探討葉酸片聯(lián)合鹽酸貝那普利片治療高血壓合并高同型半胱氨酸血癥的臨床療效。方法 選擇2015年6月—2016年6月北海市人民醫(yī)院收治的原發(fā)性高血壓合并高同型半胱氨酸血癥患者123例作為研究對象，所有患者隨機分為對照組（63例）和治療組（60例）。對照組口服鹽酸貝那普利片，10 mg/次，1次/d。治療組在對照組的基礎(chǔ)上晨起空腹口服葉酸片，0.8 mg/次，1次/d。兩組患者均連續(xù)治療3個月。觀察兩組的臨床療效，比較兩組的同型半胱氨酸水平和血壓情況。結(jié)果 治療后，對照組和治療組的總有效率分別為84.13%、96.67%，兩組比較差異具有統(tǒng)計學(xué)意義（P< 0.05）。治療后，兩組同型半胱氨酸水平均顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P< 0.05）；且治療組同型半胱氨酸水平明顯低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P< 0.05）。治療后，兩組收縮壓（SBP）、舒張壓（DBP）和脈壓差均顯著下降，同組治療前后比較差異有統(tǒng)計學(xué)意義（P< 0.05）；且治療組這些觀察指標明顯低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P< 0.05）。結(jié)論 葉酸片聯(lián)合鹽酸貝那普利片治療高血壓合并高同型半胱氨酸血癥具有較好的臨床療效，能降低同型半胱氨酸水平和血壓，安全性較好，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Folic Acid Tablets combined with Benazepril Hydrochloride Tablets in treatment of hypertension complicated with hyperhomocysteinemia. Methods Patients (123 cases) with hypertension complicated with hyperhomocysteinemia in Beihai People's Hospital from June 2015 to June 2016 were randomly divided into control group (63 cases) and treatment group (60 cases). Patients in the control group were po administered with Benazepril Hydrochloride Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Folic Acid Tablets on an empty stomach in the morning on the basis of the control group, 0.8 mg/time, once daily. Patients in two groups were treated for 3 months. After treatment, clinical efficacies were evaluated, and homocysteine levels and blood pressures in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.13% and 96.67%, respectively, and there was difference between two groups (P < 0.05). After treatment, the homocysteine levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the homocysteine levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, SBP, DBP, and pulse pressure in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Folic Acid Tablets combined with Benazepril Hydrochloride Tablets has clinical curative effect in treatment of hypertension complicated with hyperhomocysteinemia, can decrease homocysteine levels and blood pressure, with good safety, which has a certain clinical application value.