目的 探討熊去氧膽酸膠囊聯(lián)合地塞米松磷酸鈉注射液治療老年肝內(nèi)膽汁淤積性肝炎的臨床療效。方法 選取2014年12月—2016年12月重慶市大足區(qū)人民醫(yī)院收治的老年肝內(nèi)膽汁淤積性肝炎患者70例，按隨機(jī)數(shù)字法將所有患者分為對(duì)照組和治療組，每組各35例。對(duì)照組口服熊去氧膽酸膠囊，1粒/次，3次/d；治療組在對(duì)照組的基礎(chǔ)上靜脈滴注地塞米松磷酸鈉注射液，5 mg加入到10%葡萄糖500 mL中，1次/d。兩組連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的肝功能和生活質(zhì)量評(píng)分情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為71.43%、94.29%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療后，兩組總膽汁酸（TBA）、直接膽紅素（DBIL）、天冬氨酸氨基轉(zhuǎn)氨酶（AST）和丙氨酸氨基轉(zhuǎn)移酶（ALT）均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P< 0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療后，兩組腹部癥狀、全身癥狀、乏力、活動(dòng)、焦慮和情感功能評(píng)分均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P< 0.05）；且治療組這些觀察指標(biāo)明顯高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。結(jié)論 熊去氧膽酸膠囊聯(lián)合地塞米松磷酸鈉注射液治療老年肝內(nèi)膽汁淤積性肝炎具有較好的臨床效果，可改善肝功能，提高生活質(zhì)量，安全性較好，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the effect of Ursodeoxycholic Acid Capsules combined with Dexamethasone Sodium Phosphate Injection in treatment of senile intrahepatic cholestasis hepatitis. Methods Elderly patients (70 cases) with intrahepatic cholestasis hepatitis in Chongqing Dazu District People's Hospital from December 2014 to December 2016 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were po administered with Ursodeoxycholic Acid Capsules, 1 grain/time, three times daily. Patients in the treatment group were iv administered with Dexamethasone Sodium Phosphate Injection on the basis of the control group, 5 mg added into 10% glucose solution 500 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and liver function and quality of life scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.43% and 94.29%, respectively, and there was difference between two groups (P < 0.05). After treatment, TBA, DBIL, AST, and ALT in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the scores of abdominal symptoms, systemic symptoms, weakness, movement, anxiety, and emotional function in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Ursodeoxycholic Acid Capsules combined with Dexamethasone Sodium Phosphate Injection has clinical curative effect in treatment of senile intrahepatic cholestasis hepatitis, can improve liver function, and increase quality of life, with good safety, which has a certain clinical application value.