目的 探討槐杞黃顆粒聯(lián)合氫化可的松治療兒童過(guò)敏性紫癜的臨床療效。方法 收集2012年8月—2016年8月在扶風(fēng)縣中醫(yī)醫(yī)院接受治療的兒童過(guò)敏性紫癜患兒60例，根據(jù)治療方案的差別分為對(duì)照組（30例）和治療組（30例）。對(duì)照組患兒靜脈滴注注射用氫化可的松琥珀酸鈉，5～10 mg/（kg·d），2次/d，癥狀消失后逐漸減量，2周后停藥，并對(duì)癥治療。治療組患兒在對(duì)照組的基礎(chǔ)上口服槐杞黃顆粒，2～3歲半袋/次，3～12歲1袋/次，均為2次/d。兩組患兒均治療2周。評(píng)價(jià)治療后兩組患者臨床療效，同時(shí)比較兩組患兒治療前后臨床癥狀和炎性因子水平。結(jié)果 治療后，對(duì)照組和治療組總有效率分別為73.33%和96.67%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療后，治療組患兒皮疹消退時(shí)間、紫癜消退時(shí)間、關(guān)節(jié)疼痛改善時(shí)間和消化癥狀改善時(shí)間均顯著短于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療后，兩組患兒IL-4、IL-13和腫瘤壞死因子-α（TNF-α）水平均明顯低于同組治療前，而γ-干擾素（IFN-γ）水平明顯高于同組治療前，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）；且治療組患者上述炎性因子指標(biāo)改善情況明顯好于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。結(jié)論 槐杞黃顆粒聯(lián)合氫化可的松治療兒童過(guò)敏性紫癜的臨床療效顯著，可明顯改善患兒臨床癥狀和血清細(xì)胞因子水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effects of Huaiqihuang Granules combined with hydrocortisone in treatment of children with allergic purpura. Methods Children (60 cases) with allergic purpura in Fufeng County Hospital of TCM from August 2012 to August 2016 were randomly divided into control (30 cases) and treatment (30 cases) groups. Children in the control group were iv administered with Hydrocortisone Sodium Succinate for injection, 5-10 mg/(kg·d), twice daily, the dosage was gradually decreased after symptoms disappeared, and withdrawal after 2 weeks, then took symptomatic treatment. Children in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group, half bag/time for 2-3 years children, 1 bag/time for 3-12 years children, twice daily. Children in two groups were treated for 2 weeks. After treatment, clinical efficacy was evaluated, and the clinical symptom and the inflammatory factors levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.33% and 96.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, the rash and purpura regression time, joint pain and digestive symptoms improvement time in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the IL-4, IL-13 and TNF-α levels in two groups were significantly decreased, but IFN-γ levels were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the improvement of inflammatory factors levels in treatment group was significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Huaiqihuang Granules combined with hydrocortisone has significant effect in treatment of children with allergic purpura, can significantly improve the clinical symptoms and serum cytokine levels, which has a certain clinical application value.