目的 探討紅花逍遙片聯(lián)合炔雌醇環(huán)丙孕酮治療多囊卵巢綜合征患者的臨床效果。方法 收集2014年8月—2016年8月在鄭州人民醫(yī)院就診的多囊卵巢綜合征患者144例，隨機(jī)分為對(duì)照組和治療組，每組各72例。對(duì)照組患者口服炔雌醇環(huán)丙孕酮片，1片/次，連服21 d，停用7 d后開始下一療程。治療組患者在對(duì)照組的基礎(chǔ)上口服紅花逍遙片，3片/次，3次/d。兩組患者均連續(xù)治療3個(gè)月。評(píng)價(jià)治療后兩組患者臨床療效，同時(shí)比較治療前后兩組血糖指標(biāo)、性激素水平以及排卵和妊娠情況。結(jié)果 治療后，對(duì)照組總有效率為72.22%，顯著低于治療組的91.67%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療后，兩組患者空腹胰島素（FINS）和胰島素抵抗指數(shù)（HOMA-IR）較治療前顯著降低（P< 0.05）；且治療組患者FINS和HOMA-IR較對(duì)照組患者更低（P< 0.05）。治療后，兩組患者血清睪酮（TSTO）、卵泡刺激素（FSH）、黃體生成素（LH）和LH/FSH較治療前顯著降低（P< 0.05）；且治療組患者上述性激素水平降低程度明顯優(yōu)于對(duì)照組（P< 0.05）。治療后隨訪3個(gè)月發(fā)現(xiàn)，對(duì)照組患者的排卵率和妊娠率分別為66.67%、47.22%，均分別顯著低于治療組的86.11%、68.06%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。結(jié)論 紅花逍遙片聯(lián)合炔雌醇環(huán)丙孕酮治療多囊卵巢綜合征患者優(yōu)勢(shì)明顯，能降低機(jī)體性激素水平，改善胰島素抵抗、促進(jìn)排卵、提高妊娠，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Honghua Xiaoyao Tablets combined with ethinylestradiol and cyproterone in treatment of polycystic ovary syndrome. Methods Patients (144 cases) with polycystic ovary syndrome in People's Hospital of Zhengzhou from August 2014 to August 2016 were randomly divided into control and treatment groups, and each group had 72 cases. Patients in the control group were po administered with Ethinylestradiol and Cyproterone Acetate Tablets, 1 tablet/time, and they were treated for 21 d, then the next course of treatment began after withdrawal for 7 d. Patients in the treatment group were po administered with Honghua Xiaoyao Tablets on the basis of control group, 3 tablets/time, three times daily. Patients in two groups were treated for 3 months. After treatment, clinical efficacy was evaluated, and the blood glucose indexes, sex hormones levels, ovulation, and pregnancy in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 72.22%, which was significantly lower than 91.67% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the FINS and HOMA-IR in two groups were significantly decreased (P < 0.05). And the FINS and HOMA-IR in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the TSTO, FSH, LH, and LH/FSH levels in two groups were significantly decreased (P < 0.05). And the sex hormones levels in treatment group were significantly better than those in the control group (P < 0.05). Three month's follow-up after treatment, ovulation and pregnancy rate in the control group were 66.67% and 47.22%, which were significantly lower than 86.11% and 68.06% in the treatment group, respectively, and there were differences between two groups (P < 0.05). Conclusion Honghua Xiaoyao Tablets combined with ethinylestradiol and cyproterone has obvious advantages in treatment of polycystic ovary syndrome, can reduce sex hormone level, improve insulin resistance,promote ovulation and improve the pregnancy, which has a certain clinical application value.