目的 對西安市中心醫(yī)院質(zhì)子泵抑制劑在兒科的應(yīng)用情況進行分析，為規(guī)范和指導(dǎo)臨床合理用藥、加強兒童用藥監(jiān)護提供依據(jù)。方法 采用回顧性調(diào)查方法，利用醫(yī)院PASS系統(tǒng)，統(tǒng)計2015年西安市中心醫(yī)院質(zhì)子泵抑制劑在住院患兒的使用情況，針對品種選擇、適應(yīng)癥、給藥劑量、溶媒選擇及給藥途徑等分析合理性。結(jié)果 質(zhì)子泵抑制劑在住院患兒中的使用人次及銷售金額均以蘭索拉唑粉針劑為首。觀察的79份病例中，不合理用藥現(xiàn)象主要包括選藥品種不適宜、無適應(yīng)癥用藥、用法用量及給藥途徑不適宜、重復(fù)用藥等。結(jié)論 西安市中心醫(yī)院質(zhì)子泵抑制劑在患兒中的使用存在不合理現(xiàn)象，建議加強該類藥物的規(guī)范化管理，以便在提高藥效的同時降低患兒的用藥風險。

Objective To analyze the clinical use of proton pump inhibitors (PPIs) in pediatric inpatients of Xi'an Central Hospital, to provide reference for the rational use of PPIs in pediatric and strengthening supervision on children. Methods The hospital PASS system was used for statistics on the use of PPIs in pediatric inpatients in Xi'an Central Hospital in 2015 by retrospective investigation, and the rationality of using PPIs in respect of indication, drug selection, drug dosage, solvent selection, and administration route were analyzed. Results The most use times and sales amount of PPIs was Lansoprazole Injection in pediatric inpatients. In the observed patients (79 cases), the irrational phenomenon mainly included inappropriate selection of drugs, non-indication, unsuitable usage, and inappropriate route of administration, and repeated medication and so on. Conclusion There is unreasonable use of PPIs in pediatric inpatients in Xi'an Central Hospital. Rational use of PPIs should be strengthened to improve the efficacy of the drug at the same time reduce the associated risk of adverse effects.