骨纖維異樣增殖癥（FD）是一種先天性、非遺傳性的類腫瘤疾病。在FD患者中骨痛非常普遍，但骨痛的發(fā)生機制仍然不明。目前沒有理想的藥物能夠徹底根治骨痛?，F(xiàn)階段的治療藥物主要包括非甾體藥物、麻醉性止痛藥和二膦酸鹽類藥物如帕米膦酸二鈉、唑來膦酸鹽、阿侖膦酸鈉、托珠單抗和地諾塞麥，主要對上述FD骨痛的治療藥物進(jìn)行綜述。

Fibrous dysplasia (FD) is a congenital and nonheritable genetic disorder characterized by tumor-like disease. Bone pain is common in FD patients, but the mechanism is still unknown. There are no ideal drugs to cure pain of FD thoroughly. Until now, therapeutic drugs for treatment of fibrous dysplasia patients with bone pain include non steroid anti inflammatory drug, narcotic analgesics, and bisphosphonates such pamidronate disodium, zoledronate, alendronate sodium, astocilizumab, and denosumab. Research progress on those therapeutic drugs for treatment of fibrous dysplasia patients with bone pain are reviewed in this paper.