目的 探討小兒豉翹清熱顆粒聯(lián)合炎琥寧注射液治療小兒上呼吸道感染的臨床療效。方法 選取2016年1月-2017年1月在鄭州大學(xué)附屬洛陽中心醫(yī)院接受治療的小兒上呼吸道感染患者104例，根據(jù)治療方案的差別分為對照組（52例）和治療組（52例）。對照組患兒靜脈滴注炎琥寧注射液，0.2~0.4 mL/kg，1次/d。治療組在對照組的基礎(chǔ)上口服小兒豉翹清熱顆粒，1~3歲患兒2~3 g/次，4~6歲患兒3~4 g/次，7~10歲患兒4~6 g/次，3次/d。兩組患兒治療1周。評價兩組患兒臨床療效，同時比較治療前后兩組患兒臨床癥狀消失時間和血清學(xué)指標變化。結(jié)果 治療后，對照組和治療組總有效率分別為80.65%、98.08%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組患兒的退熱、止咳、咽喉紅腫、腹瀉及鼻塞流涕等消失時間均短于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患兒血清超敏C反應(yīng)蛋白（hs-CRP）、白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）和降鈣素原（PCT）水平均顯著降低，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組患兒降低水平明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 小兒豉翹清熱顆粒聯(lián)合炎琥寧注射液治療小兒上呼吸道感染療效顯著，可有效改善臨床癥狀及降低血清炎癥因子水平，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Xiao'er Chiqiao Qingre Granules combined with Potassium Sodium Dehydroandrographolide Succinate Injection in treatment of children with upper respiratory tract infection. Methods Children (104 cases) with upper respiratory tract infection in Luoyang Central Hospital Affiliated to Zhengzhou University from January 2016 to January 2017 were divided into control (52 cases) and treatment (52 cases) groups based on different treatments. Children in the control group were iv administered with Potassium Sodium Dehydroandrographolide Succinate Injection, 0.2-0.4 mL/kg, once daily. Children in the treatment group were po administered with Xiao'er Chiqiao Qingre Granules on the basis of the control group, 2-3 g/time for 1-3 years children, 3-4 g/time for 4-6 years children, 4-6 g/time for 7-10 years children, three times daily. Children in two groups were treated for 1 week. After treatment, clinical efficacy was evaluated, and the disappearance time of clinical symptoms, serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.65% and 98.08%, respectively, and there were differences between two groups (P<0.05). After treatment, the disappearance time of fever, cough, swelling of the throat, diarrhea, and stuffy running nose in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the hs-CRP, IL-6, TNF-α, and PCT levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decreased degree in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Xiao'er Chiqiao Qingre Granules combined with Potassium Sodium Dehydroandrographolide Succinate Injection has good clinical efficacy in treatment of children with upper respiratory tract infection, can effectively improve the clinical symptoms with decreasing serum inflammatory factors levels, which has a certain clinical application value.