2S)和一氧化氮(NO)水平,以及癥狀和體征恢復(fù)時(shí)間。結(jié)果 治療后,對(duì)照組臨床總有效率為83.72%,顯著低于治療組的93.02%,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組腦脊液和外周血中CRP、TNF-α、H2S和NO水平均顯著降低,同組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療后治療組上述因子水平均低于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,治療組腦脊液和外周血中白細(xì)胞恢復(fù)時(shí)間以及體溫恢復(fù)時(shí)間和意識(shí)恢復(fù)時(shí)間明顯短于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 地塞米松聯(lián)合美羅培南治療小兒化膿性腦膜炎臨床效果顯著,可使患兒盡快恢復(fù)正常體溫和意識(shí),具有一定的臨床推廣應(yīng)用價(jià)值。;Objective To investigate the efficacy of dexamethasone combined with meropenem in treatment of purulent meningitis in children. Methods Children (86 cases) with purulent meningitis in Chengdu Women and Children's Center Hospital from November 2014 to March 2016 were randomly divided into control (43 cases) and treatment (43 cases) groups. Children in the control group were iv administered with Meropenem for injection, 20 mg/kg, twice daily. Children in the treatment group were iv administered with Dexamethasone Sodium Phosphate Injection on the basis of the control group, the dosage for the first three days was that 15 mg/d added into 5% glucose injection 250 mL, and adjust dosage according to symptom improvement, the final dose was 10 mg/d. Children in two groups were treated for 14 d. After treatment, clinical efficacy was evaluated, and the CRP, TNF-α, H2S, and NO levels in the cerebrospinal fluid and peripheral blood, and the recovery time of symptoms and signs in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 83.72%, which was significantly lower than 93.02% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the CRP, TNF-α, H2S, and NO levels in the cerebrospinal fluid and peripheral blood in two groups were significantly decreased, the difference was statistically significant in the same group (P<0.05). And these factor levels were lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the leukocyte recovery time in the cerebrospinal fluid and peripheral blood, and body temperature and consciousness recovery time in the treatment group were significantly shorter than those in the control group, with significant difference between two groups (P<0.05). Conclusion Dexamethasone combined with meropenem has significant clinical effect in treatment of purulent meningitis in children, can recover normal body temperature and consciousness as soon as possible, which has a certain clinical application value."/>

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首頁 > 過刊瀏覽>2017年第32卷第8期 >2017,32(8):1491-1494. DOI:10.7501/j.issn.1674-5515.2017.08.022
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地塞米松聯(lián)合美羅培南治療小兒化膿性腦膜炎的臨床研究

Clinical study on dexamethasone combined with meropenem in treatment of purulent meningitis in children

發(fā)布日期:2017-08-22