目的 探討小兒柴桂退熱顆粒聯(lián)合注射用炎琥寧治療小兒急性上呼吸道感染的臨床療效。方法 選取2015年6月-2016年9月北京市門頭溝區(qū)婦幼保健院收治的急性上呼吸道感染患兒130例，所有患兒按照隨機(jī)數(shù)字表法分為對照組和治療組，每組各65例。對照組靜脈滴注注射用炎琥寧，15 mg/kg加入到5%葡萄糖溶液250 mL中，1次/d。治療組在對照組基礎(chǔ)上口服小兒柴桂退熱顆粒，年齡<4歲：4 g/次，4~6歲：6 g/次，年齡≥ 7歲：8 g/次，3次/d。兩組患者均連續(xù)治療7 d。觀察兩組的臨床療效，比較兩組的臨床癥狀改善和炎癥因子水平。結(jié)果 治療后，對照組和治療組的總有效率分別為81.54%、92.31%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組退熱時(shí)間、咽腫消退時(shí)間和止涕時(shí)間明顯短于對照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組高敏C反應(yīng)蛋白（hs-CRP）、腫瘤壞死因子-α（TNF-α）和白細(xì)胞介素-6（IL-6）水平均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 小兒柴桂退熱顆粒聯(lián)合注射用炎琥寧治療小兒急性上呼吸道感染具有較好的臨床療效，可改善患兒的臨床癥狀，減輕炎癥反應(yīng)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the effect of Xiaoer Chaigui Tuire Granules combined with Potassium sodium Dehydroandroandrographolide Succinate for injection in treatment of acute upper respiratory tract infection in children. Methods Children (130 cases) with acute upper respiratory tract infection in Beijing Mentougou District Maternal and Child Care Service Centre from June 2015 to September 2016 were randomly divided into control and treatment groups, and each group had 65 cases. Patients in the control group were iv administered with Potassium Sodium Pehydroandroandrographolide Succinate for injection, 15 mg/kg added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Xiaoer Chaigui Tuire Granules on the basis of the control group, age < 4 years:4 g/time, 4 years ≤ age < 7 years:6 g/time, 7 years ≥ age:8 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and clinical symptom improvement and inflammatory factors levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.54% and 92.31%, respectively, and there was difference between two groups (P<0.05). After treatment, pyretolysis time, pharyngeal swelling subsided time, and nasal stopping time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of hs-CRP, TNF-α, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xiaoer Chaigui Tuire Granules combined with Potassium sodium Dehydroandroandrographolide Succinate for injection has clinical curative effect in treatment of acute upper respiratory tract infection in children, can improve clinical symptoms, and relieve inflammatory reaction, which has a certain clinical application value.