[關(guān)鍵詞]
[摘要]
目的 探究婦科千金片聯(lián)合鹽酸左氧氟沙星片治療慢性宮頸炎的臨床療效。方法 選取2015年11月-2016年11月廣元市婦幼保健院婦產(chǎn)科收治的慢性宮頸炎患者155例,所有患者隨機分為對照組(77例)和治療組(78例)。對照組口服鹽酸左氧氟沙星片,1片/次,3次/d。治療組在對照組基礎(chǔ)上口服婦科千金片,6片/次,3次/d。兩組患者連續(xù)治療14 d。觀察兩組的臨床療效,比較兩組的宮頸糜爛、炎癥因子和不良反應(yīng)。結(jié)果 治療后,對照組和治療組的總有效率分別為87.01%、97.44%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,對照組和治療組的宮頸糜爛恢復(fù)正常率分別為50.65%、69.23%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組IL-2、IL-10和hs-CRP水平均顯著降低,同組治療前后比較差異有統(tǒng)計學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)明顯低于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后,對照組和治療組的不良反應(yīng)發(fā)生率分別為15.58%、3.85%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 婦科千金片聯(lián)合鹽酸左氧氟沙星片治療慢性宮頸炎具有較好的臨床療效,能顯著改善宮頸糜爛,調(diào)節(jié)炎癥因子水平,安全性較好,具有一定的臨床推廣應(yīng)用價值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Fuke Qianjin Tablets combined with Levofloxacin Hydrochloride Tablets in treatment of chronic cervicitis. Methods Patients (155 cases) with chronic cervicitis in Maternal and Child Health Hospital of Guangyuan from November 2015 to November 2016 were randomly divided into the control group (77 cases) and the treatment group (78 cases). Patients in the control group were po administered with Levofloxacin Hydrochloride Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Fuke Qianjin Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and cervical erosion, inflammatory factor, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 87.01% and 97.44%, respectively, and there was difference between two groups (P<0.05). After treatment, the recovery rate of cervical erosion in the control and treatment groups were 50.65% and 69.23%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of IL-2, IL-10, and hs-CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the incidence rate of adverse reaction in the control and treatment groups were 72.5% and 92.5%, respectively, and there was difference between two groups (P<0.05). Conclusion Fuke Qianjin Tablets combined with Levofloxacin Hydrochloride Tablets has clinical curative effect in treatment of chronic cervicitis, can improve cervical erosion, and regulate inflammatory factor levels, with good safety, which has a certain clinical application value.
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