目的 比較索利那新和奧昔布寧治療老年經(jīng)尿道前列腺電切術(shù)后膀胱痙攣的臨床療效。方法 選取2016年2月-2017年2月在儋州市人民醫(yī)院治療的老年經(jīng)尿道前列腺電切術(shù)后膀胱痙攣患者90例，按照治療方法的不同分為對(duì)照組（45例）和治療組（45例）。對(duì)照組口服鹽酸奧昔布寧片，5 mg/次，2次/d。治療組口服琥珀酸索利那新片，5 mg/次，2次/d。所有患者均在拔出尿管后3 d停藥。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較治療前后兩組患者膀胱痙攣次數(shù)和持續(xù)時(shí)間，尿頻和尿急次數(shù)，OABSS和PPBC評(píng)分。結(jié)果 治療后，對(duì)照組和治療組總有效率分別為82.22%、97.78%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療2、3 d后，治療組膀胱痙攣次數(shù)和持續(xù)時(shí)間均明顯少于對(duì)照組（P<0.05）。治療1、3 d后，治療組患者尿頻、尿急次數(shù)均顯著少于對(duì)照組（P<0.05）。治療后，兩組OABSS和PPBC評(píng)分均明顯下降（P<0.05）；且治療組患者OABSS和PPBC評(píng)分明顯低于對(duì)照組（P<0.05）。結(jié)論 索利那新治療老年經(jīng)尿道前列腺電切術(shù)后膀胱痙攣效果顯著，可有效改善患者臨床癥狀，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To compare the clinical efficacy of solifenacin and oxybutynin in treatment of senile bladder spasm after transurethral resection of prostate. Methods Patients (90 cases) with bladder spasm after transurethral resection of prostate in Danzhou People's Hospital from February 2016 to February 2017 were divided into control (45 cases) and treatment (45 cases) groups based on different treatment. Patients in the control group were po administered with Oxybutynin Hydrochloride Tablets, 5 mg/time, twice daily. Patients in the treatment group were po administered with Solifenacin Succinate Tablets, 5 mg/time, twice daily. Patients in two groups were withdrew after pulling out the catheter for 3 d. After treatment, clinical efficacy was evaluated, and the frequency and duration of bladder spasm, the frequency of micturition and urgency, OABSS and PPBC scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.22% and 97.78%, respectively, and there were differences between two groups (P<0.05). After treatment for 2 and 3 d, the frequency and duration of bladder spasm in the treatment group were significantly less than patients in the control group (P<0.05). After treatment for 1 and 3 d, the frequency of micturition and urgency in the treatment group were significantly less than patients in the control group (P<0.05). After treatment, the OABSS and PPBC scores in two groups were significantly decreased (P<0.05). And the OABSS and PPBC scores in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Solifenacin and oxybutynin has significant efficacy in treatment of senile bladder spasm after transurethral resection of prostate, can effectively improve the clinical symptoms, which has a certain clinical application value.