目的 探討丁苯酞軟膠囊治療腦梗死的臨床療效。方法 選取2014年5月-2016年5月新汶礦業(yè)集團萊蕪中心醫(yī)院神經(jīng)內(nèi)分泌科收治的腦梗死患者97例為研究對象，所有患者隨機分為對照組（49例）和治療組（48例）。對照組在溶栓24 h無出血征象后口服阿司匹林腸溶片，300 mg/次，1次/d。治療組口服丁苯酞軟膠囊，0.2 g/次，3次/d。兩組患者均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組的血管內(nèi)皮功能和血清同型半胱氨酸（Hcy）水平。結(jié)果 治療后，對照組和治療組的總有效率分別為55.1%、77.1%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組內(nèi)皮素-1（ET-1）、Hcy水平顯著降低，而一氧化氮（NO）、內(nèi)皮型一氧化氮合酶（eNOS）水平顯著升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計學(xué)意義。結(jié)論 丁苯酞軟膠囊治療腦梗死具有較好的臨床療效，能降低患者ET-1和Hcy水平，升高NO、eNOS水平，改善血管內(nèi)皮功能，緩解神經(jīng)功能損傷，具有一定臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Butylphthalide Soft Capsules in treatment of cerebral infarction. Methods Patients (97 cases) with cerebral infarction in Department of Neuroendocrine of Laiwu Center Hospital of Xinwen Mining Industry Group from May 2014 to May 2016 were randomly divided into the control group (49 cases) and the treatment group (48 cases). Patients in the control group were po administered with Aspirin Enteric-coated Tablets after thrombolysis for 24 h without signs of bleeding, 300 mg/time, once daily. Patients in the treatment group were po administered with Butylphthalide Soft Capsules, 0.2 g/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and vascular endothelial function and serum Hcy levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 55.1% and 77.1%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of endothelin 1 (ET-1) and homocysteine (Hcy) in two groups were significantly decreased, but the levels of nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). There were no significant differences of adverse reaction rates between two groups. Conclusion Butylphthalide Soft Capsules has clinical curative effect in treatment of cerebral infarction, and can decrease the levels of ET-1 and Hcy, increase the levels of NO and eNOS, improve vascular endothelial function, and relieve nerve function damage, which has a certain clinical application value.