目的 探討注射用還原型谷胱甘肽聯(lián)合注射用門冬氨酸鳥氨酸治療嬰兒肝炎綜合征的臨床療效。方法 選擇2015年12月-2016年12月漯河市第一人民醫(yī)院收治嬰的兒肝炎綜合征患兒70例作為研究對(duì)象，全部患兒隨機(jī)分為對(duì)照組和治療組，每組各35例。對(duì)照組靜脈滴注注射用門冬氨酸鳥氨酸，0.5 g加入到5%葡萄糖溶液50 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注注射用還原型谷胱甘肽，0.3 g加入到5%葡萄糖溶液30 mL中，1次/d。兩組患兒均連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組生化指標(biāo)和炎癥因子。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為88.6%、97.1%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組丙氨酸氨基轉(zhuǎn)移酶（ALT）、總膽酸（TBA）、總膽紅素（TBIL）、直接膽紅素（DBIL）和谷氨酰轉(zhuǎn)肽酶（GGT）水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組白細(xì)胞介素-6（IL-6）和腫瘤壞死因子-α（TNF-α）水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 注射用還原型谷胱甘肽聯(lián)合注射用門冬氨酸鳥氨酸治療嬰兒肝炎綜合征具有較好的臨床療效，能顯著降低ALT、TBA、TBIL、DBIL和GGT水平，減輕炎癥水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To study clinical effect of Reduced Glutathione for injection combined with Ornithine Aspartate for injection in treatment of infantile hepatitis syndrome. Methods Children (70 cases) with hepatitis syndrome in Luohe Central Hospital from December 2015 to December 2016 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were iv administered with Reduced Glutathione for injection, 0.5 g added into 5% glucose solution 50 mL, once daily. Patients in the treatment group were iv administered with Ornithine Aspartate for injection on the basis of the control group, 0.3 g added into 5% glucose solution 30 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and biochemical indexes and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 88.6% and 97.1%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of ALT, TBA, TBIL, DBIL, and GGT in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of IL-6 and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Reduced Glutathione for injection combined with Ornithine Aspartate for injection has clinical curative effect in treatment of infantile hepatitis syndrome, and can significantly decrease the levels of ALT, TBA, TBIL, DBIL, and GGT, and reduce inflammation levels, which has a certain clinical application value.