目的 探討復方斑鰲膠囊聯(lián)合FOLFOX6方案治療老年結(jié)腸癌肝轉(zhuǎn)移的臨床療效。方法 將延安大學附屬醫(yī)院2011年11月-2013年11月接受治療的老年結(jié)腸癌肝轉(zhuǎn)移患者98例，隨機分為對照組和治療組，每組各49例，對照組患者給予FOLFOX6方案進行化療：氟尿嘧啶注射液2 800 mg/m²持續(xù)泵入46 h，第1天靜脈滴注亞葉酸鈣注射液400 mg/m²；第1天靜脈滴注注射用奧沙利鉑85 mg/m²，2周為1個療程。治療組患者在對照組的基礎(chǔ)上口服復方斑鰲膠囊，3粒/次，2次/d。兩組均治療3個月。治療后對患者進行為期3年的隨訪，觀察兩組的臨床療效，比較兩組的免疫功能指標和不良反應情況。結(jié)果 治療后，對照組的客觀緩解率和疾病控制率分別為36.7%、77.5%；治療組的分別為46.9%、89.7%；兩組客觀緩解率和疾病控制率比較差異具有統(tǒng)計學意義（P<0.05）。治療組1、2、3年的生存率分別為95.9%、87.7%、63.2%，均顯著高于對照組的83.6%、65.3%、46.9%，兩組比較差異均具有統(tǒng)計學意義（P<0.05）。治療組的腹瀉腹痛、惡心嘔吐、白細胞計數(shù)下降、周圍神經(jīng)病變和皮疹的不良反應發(fā)生率均明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 復方斑鰲膠囊聯(lián)合FOLFOX6方案治療老年結(jié)腸癌肝轉(zhuǎn)移患者療效確切，能夠有效提高患者免疫功能，且不良反應小，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Compound Banmao Capsules combined with FOLFOX6 chemotherapy in treatment of elderly hepatic metastasis of colonic carcinoma. Methods Elderly patients (98 cases) with hepatic metastasis of colonic carcinoma in Yan'an University Affiliated Hospital from November 2011 to November 2013 were randomly divided into control and treatment groups, and each group had 49 cases. The patients in the control group were treated by FOLFOX6 chemotherapy. The patients in the control group were pumped with Fluorouracil Injection for 46 h, 2 800 mg/m². They were iv administered with Calcium Folinate Injection in the first day, 400 mg/m². And they were also iv administered with Oxaliplatin for injection, 85 mg/m². Two weeks were one course. The patients in the treatment group were po administered with Compound Banmao Capsules, 3 grains/time, twice daily. Two groups were treated for 3 months. They were followed-up for 3 years after treatment. The efficacy was evaluated, and the immune function indexes and adverse reactions in two groups were compared. Results After treatment, the objective response rate and disease control rate of control group were 36.7% and 77.5%, while those index of treatment group were 46.9% and 89.7%, and there were differences between two groups (P<0.05). Survival rate of 1, 2, and 3 years in the treatment (95.9%, 87.7%, and 63.2%) were higher than those in control group (83.6%, 65.3%, and 46.9%) with significant difference (P<0.05). The incidences of diarrhea and stomachache, nausea and vomiting, leucopenia, peripheral neuropathy, and rash in treatment group were significantly lower than those in the control group, and the differences were statistically significant between two groups (P<0.05). Conclusion Compound Banmao Capsules combined with FOLFOX6 chemotherapy has a good effect in treatment of elderly hepatic metastasis of colonic carcinoma, can promote the immune function with less adverse reactions, which has a certain clinical application value.

陜西省自然科學基礎(chǔ)研究計劃項目（2012JQ4016）；西安交通大學基本科研業(yè)務費資助項目（Xjj2012072）