目的 探討芪參益氣滴丸聯(lián)合薯蕷皂苷片治療冠心病心絞痛的臨床療效。方法 選取2016年2月-2017年2月在中國(guó)人民解放軍第四軍醫(yī)大學(xué)第二附屬醫(yī)院進(jìn)行治療104例冠心病心絞痛患者為研究對(duì)象，依據(jù)用藥的差別分為對(duì)照組（52例）和治療組（52例），對(duì)照組口服薯蕷皂苷片，160 mg/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服芪參益氣滴丸，0.5 g/次，3次/d。兩組患者均治療2周。評(píng)價(jià)兩組患兒臨床療效，同時(shí)比較治療前后兩組患兒心電圖療效、心絞痛發(fā)作次數(shù)和持續(xù)時(shí)間、血清學(xué)指標(biāo)和心功能指標(biāo)。結(jié)果 治療后，對(duì)照組患者的總有效率為80.77%，顯著低于治療組的96.15%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，對(duì)照組和治療組患者心電圖療效分別為69.23%、90.38%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者心絞痛發(fā)作次數(shù)和持續(xù)時(shí)間均顯著減少（P<0.05）；且治療組患者心絞痛發(fā)作次數(shù)和持續(xù)時(shí)間比對(duì)照組更少（P<0.05）。治療后，兩組患者血清白細(xì)胞介素-1β（IL-1β）、IL-18、妊娠相關(guān)血漿蛋白A（PAPP-A）、核轉(zhuǎn)錄因子-κB（NF-κB）水平均明顯下降（P<0.05）；且治療組上述血清學(xué)指標(biāo)顯著低于對(duì)照組（P<0.05）。治療后，兩組患者左心室射血分?jǐn)?shù)（LVEF）和心排血量（CO）顯著增高，左室收縮末內(nèi)徑（LVESD）顯著縮短，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者上述指標(biāo)比對(duì)照組改善更明顯（P<0.05）。結(jié)論 芪參益氣滴丸聯(lián)合薯蕷皂苷片治療冠心病心絞痛可有效減少心絞痛發(fā)作次數(shù)，降低機(jī)體炎癥反應(yīng)和改善心功能，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Qishen Yiqi Dropping Pills combined with Discornin Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients (104 cases) with angina pectoris of coronary heart disease in the Second Affiliated Hospital of the Fourth Military Medical University from February 2016 to February 2017 were divided into control (52 cases) and treatment (52 cases) groups according to different treatments. Patients in the control group were po administered with Discornin Tablets, 160 mg/time, twice daily. Patients in the treatment group were po administered with Qishen Yiqi Dropping Pills on the basis of the control group, 0.5 g/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the ECG curative effect, the frequency and duration of angina pectoris, serological indexes and cardiac function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.77%, which was significantly lower than 96.15% in the treatment group, and the difference was statistically significant between two groups (P<0.05). After treatment, the ECG curative effect in the control and treatment groups were 69.23% and 90.38%, respectively, and there were differences between two groups (P<0.05). After treatment, the frequency and duration of angina pectoris in two groups were significantly decreased (P<0.05). And the frequency and duration of angina pectoris in the treatment group was significantly less than those in the control group (P<0.05). After treatment, the serum IL-1β, IL-18, PAPP-A and NF-κB level in two groups was significantly decreased (P<0.05). And the serological indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the LVEF and CO in two groups was significantly increased, but LVESD was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these cardiac function indexes in the treatment group improved more obviously than that in the control group (P<0.05). Conclusion Qishen Yiqi Dropping Pills combined with Discornin Tablets can effectively reduce the frequency of angina pectoris and inflammation reaction and improve cardiac function in treatment of angina pectoris of coronary heart disease, which has a certain clinical application value.