目的 探究丹參川芎嗪注射液聯(lián)合阿托伐他汀鈣片治療急性腦梗死的臨床療效。方法 選取2013年6月-2016年6月在西安交通大學(xué)附屬紅會(huì)醫(yī)院治療的急性腦梗死患者203例為研究對(duì)象，患者入院后按計(jì)算機(jī)隨機(jī)號(hào)碼分為對(duì)照組（98例）和治療組（105例）。對(duì)照組口服阿托伐他汀片，20 mg/次，1次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注丹參川芎嗪注射液，10 mL加入到5%葡萄糖注射液250 mL中，1次/d。兩組均連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組的美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分、日常生活能力（ADL）評(píng)分、血液流變學(xué)指標(biāo)和隨訪情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為85.7%、96.2%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療14 d后，兩組NIHSS評(píng)分均顯著降低，而ADL評(píng)分均顯著上升，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于同期對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血小板聚集率、血漿纖維蛋白原和血漿黏度明顯下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療90、180 d后，兩組ADL評(píng)分均顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組ADL評(píng)分明顯高于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 丹參川芎嗪注射液聯(lián)合阿托伐他汀片治療急性腦梗死具有較好的臨床療效，可改善腦神經(jīng)功能，調(diào)節(jié)血液流變學(xué)指標(biāo)，改善預(yù)后，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Atorvastatin Calcium Tablets in treatment of acute cerebral infarction. Methods Patients (203 cases) with acute cerebral infarction in Red Cross Hospital Affiliated to Xi'an Jiao Tong University from June 2013 to June 2016 were randomly divided into control group (98 cases) and treatment group (105 cases). Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NIHSS scores, ADL scores, blood rheology indexes, and follow-up in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.7% and 96.2%, respectively, and there was difference between two groups (P<0.05). After treatment for 14 d, the NIHSS scores in two groups were significantly decreased, but the ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, platelet aggregation rate, plasma fibrinogen, and plasma viscosity in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment for 90, 180 d, the ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the ADL score in the treatment group was significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Atorvastatin Calcium Tablets has clinical curative effect in treatment of acute cerebral infarction, can improve brain nerve function, regulate blood rheology index, and improve the prognosis, which has a certain clinical application value.