目的 探討蒲地藍(lán)消炎口服液聯(lián)合莪術(shù)油葡萄糖注射液治療兒童皰疹性咽峽炎的臨床療效。方法 選取陜西省人民醫(yī)院兒童病院2016年5月-2017年5月收治的92例皰疹性咽峽炎患兒為研究對象，隨機(jī)分為對照組和治療組，每組各46例。對照組患兒靜脈滴注莪術(shù)油葡萄糖注射液10 mg/（kg·d），1次/d。治療組在對照組基礎(chǔ)上口服蒲地藍(lán)消炎口服液，10 mL/次，3次/d。兩組患兒均連續(xù)治療1周。評價兩組患兒臨床療效，同時比較治療前后兩組患兒臨床癥狀和體征消失時間以及血清炎性因子水平。結(jié)果 治療后，對照組患者總有效率為86.96%，顯著低于治療組的97.83%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組臨床癥狀、發(fā)熱和皰疹消退時間均顯著短于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患兒血清白細(xì)胞介素-6（IL-6）、IL-10和腫瘤壞死因子-α（TNF-α）水平均顯著下降，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組患兒血清炎性因子水平顯著低于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 蒲地藍(lán)消炎口服液聯(lián)合莪術(shù)油葡萄糖注射液治療兒童皰疹性咽峽炎，可明顯縮短臨床癥狀和體征消失時間，降低患兒炎性水平，具有一定的臨床推廣應(yīng)用價值。

Objective To study the clinical effect of Pudilan Xiaoyan Oral Liquid combined with Zedoary Turmeric Oil and Glucose Injection in treatment of children herpangina. Methods Children (92 cases) with herpangina in Childrens' Hospital of Shaanxi Provincial People's Hospital from May 2016 to May 2017 were randomly divided into control and treatment groups, and each group had 46 cases. Children in the control group were iv administered with Zedoary Turmeric Oil and Glucose Injection, the dosage was 10 mg/(kg·d), once daily. Children in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Children in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms and signs, and serum levels of IL-6, IL-10 and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 86.96%, which was significantly lower than 97.83% in the treatment group, and the difference was statistically significant between two groups (P<0.05). After treatment, the disappearance time of clinical symptoms, fever and herpes in the treatment group was shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the serum IL-6, IL-10 and TNF-α level in two groups was significantly decreased, the difference was statistically significant in the same group (P<0.05). And the serum inflammatory factor level in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Zedoary Turmeric Oil and Glucose Injection can significantly shorten the disappearance time of clinical symptoms and signs, and reduce the inflammatory level in treatment of children herpangina, which has a certain clinical application value.