目的 探討銀杏達(dá)莫注射液聯(lián)合胸腺法新治療自發(fā)性腹膜炎的臨床療效。方法 選取2015年2月-2017年6月費(fèi)縣人民醫(yī)院收治的92例自發(fā)性腹膜炎患者，隨機(jī)分為對照組和治療組，每組各46例。對照組皮下注射注射用胸腺法新，1.6mg/次，2次/d。治療組在對照組治療基礎(chǔ)上靜脈滴注銀杏達(dá)莫注射液，25 mL/次，1次/d。兩組均連續(xù)治療2周。觀察兩組的臨床療效，比較兩組臨床癥狀消失時間，比較兩組治療前后肝功能和炎癥因子水平的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別為71.74%、91.30%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療組發(fā)熱、腹痛、腹脹、反跳痛消失時間均顯著短于對照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清白蛋白（ALB）、白細(xì)胞介素-10（IL-10）均顯著增加，谷氨酸氨基轉(zhuǎn)移酶（ALT）、腫瘤壞死因子-α（TNF-α）、IL-6顯著降低，治療組總膽紅素（TBIL）顯著降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組TBIL、ALT、TNF-α、IL-6顯著低于對照組，IL-10水平高于對照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 銀杏達(dá)莫注射液聯(lián)合胸腺法新治療自發(fā)性腹膜炎療效顯著，可縮短臨床癥狀消失時間，改善肝功能，促進(jìn)炎癥介質(zhì)的吸收，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Ginkgo Leaf Extract and Dipyridamole Injection combined with thymalfasin in treatment of spontaneous peritonitis. Methods Patients (82 cases) with spontaneous peritonitis in Feixian County People's Hospital from February 2015 to June 2017 were randomly divided into control (46 cases) and treatment (46 cases) groups. Patients in the control group were iv administered with Thymalfasin for Injection, 1.6 mg/time, twice daily. Patients in the treatment group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of the control group, 25 mL/time, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and clinical symptoms disappeared time, liver function levels and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 71.74% and 91.30%, respectively, and there was difference between two groups (P<0.05). The disappeared time of fever, abdominal pain, abdominal distension and rebound pain in the treatment group were significantly shorter than those in the treatment group, and there was difference between two groups (P<0.05). After treatment, ALB and IL-10 in two groups were significantly increased, but ALT, TNF-α, and IL-6 in two groups were significantly decreased. TBIL in the treatment group was significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, TBIL, ALT, TNF-α, and IL-6 in the treatment group were lower than those in the control group, but IL-10 was higher than that in the control group, and there was difference between two groups (P<0.05). Conclusion Ginkgo Leaf Extract and Dipyridamole Injection combined with thymalfasin has a significant effect in treatment of spontaneous peritonitis, and can shorten clinical symptoms disappeared time, also can improve liver function and promote absorption of inflammatory mediators, which has a certain clinical application value.