目的 探究葛根素注射液聯(lián)合阿替洛爾片治療急性心肌梗死的臨床療效。方法 選取2014年1月-2016年6月湖北醫(yī)藥學院附屬人民醫(yī)院收治的急性心肌梗死患者98例為研究對象，所有患者隨機分為對照組和治療組，每組各49例。對照組口服阿替洛爾片，6.25~12.5 mg/次（依據(jù)心率的快慢調(diào)整劑量），2次/d。治療組在對照組基礎上靜脈滴注葛根素注射液，300 mg加入到5%葡萄糖注射液500 mL中，1次/d。兩組患者連續(xù)治療14 d。觀察兩組的臨床療效，比較兩組的心功能指標和血清酶學指標。結(jié)果 治療后，對照組和治療組的總有效率分別為71.43%、91.84%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組左室射血分數(shù)（LVEF）、左室短軸縮短率（LVFS）、每搏心輸出量（SV）均明顯升高，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）水平均明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 葛根素注射液聯(lián)合阿替洛爾片治療急性心肌梗死具有較好的臨床療效，能改善心功能，調(diào)節(jié)血清CK和CK-MB水平，具有一定臨床推廣應用價值。

Objective To explore the clinical effect of Puerarin Injection combined with Atenolol Tablets in treatment of acute myocardial infarction. Methods Patients (98 cases) with acute myocardial infarction in the Affiliated People's Hospital of Hubei Medical College from January 2014 to June 2016 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Atenolol Tablets, 6.25-12.5 mg/time, twice daily. Patients in the treatment group were iv administered with Puerarin Injection on the basis of the control group, 300 mL added into 5% glucose solution 500 mL, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and cardiac function indexes and serum enzyme indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.43% and 91.84%, respectively, and there was difference between two groups (P<0.05). After treatment, LVEF, LVFS, and SV in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CK and CK-MB in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Puerarin Injection combined with Atenolol Tablets has clinical curative effect in treatment of acute myocardial infarction, can improve cardiac function, regulate the levels of CK and CK-MB, which has a certain clinical application value.