目的 探究健兒止瀉顆粒聯(lián)合蒙脫石散治療小兒腹瀉的臨床療效。方法 選取2015年6月-2017年3月新疆醫(yī)科大學第一附屬醫(yī)院收治的腹瀉患兒102例為研究對象，采取隨機數(shù)表法將患兒分為對照組和治療組，每組各51例。對照組口服蒙脫石散，年齡<1歲：1/3袋/次，年齡1~3歲：1/2袋/次，年齡≥ 3歲：1袋/次，3次/d。治療組在對照組基礎上開水沖服健兒止瀉顆粒，年齡<1歲：6 g/次，年齡1~5歲：6~12 g/次，年齡≥ 5歲：12~18 g/次，3次/d。兩組患兒均連續(xù)治療7 d。觀察兩組的臨床療效，比較兩組的臨床癥狀改善時間和免疫功能指標。結(jié)果 治療后，對照組和治療組的總有效率分別為92.16%、100.00%，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療后，治療組止瀉時間、止吐時間、腹痛改善時間、退熱時間、脫水糾正時間均短于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、CD⁴⁺/CD⁸⁺水平均顯著升高，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且治療組這些觀察指標明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 健兒止瀉顆粒聯(lián)合蒙脫石散治療小兒腹瀉具有較好的臨床療效，可改善臨床癥狀，調(diào)節(jié)免疫指標，安全性較好，具有一定的臨床推廣應用價值。

Objective To explore the clinical efficacy of Jian'er Zhixie Granules combined with Montmorillonite Powder in treatment of infantile diarrhea. Methods Children (102 cases) with diarrhea in the First Affiliated Hospital of Xinjiang Medical University from June 2015 to March 2017 were randomly divided into control and treatment groups, and each group had 51 cases. Children in the control group were po administered with Montmorillonite Powder, age < 1 year:1/3 bag/time, 1 year ≤ age < 3 years:1/2 bag/time, age ≥ 3 years:1 bag/time, three times daily. Patients in the treatment group were po administered with Jian'er Zhixie Granules on the basis of the control group, age < 1 year:6 g/time, 1 year ≤ age < 5 years:6-12 g/time, age ≥ 3 years:12-18 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the time of symptom improvement and the immune function indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 92.16% and 100.00%, respectively, and there was difference between two groups (P<0.05). After treatment, antidiarrheal time, antiemetic time, the time of abdominal pain improvement, antipyretic time, and dehydration correction time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of IgA, IgG, and CD⁴⁺/CD⁸⁺ in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Jian'er Zhixie Granules combined with Montmorillonite Powder has clinical curative effect in treatment of infantile diarrhea, can improve clinical symptoms, and regulate immune function indexes, with good safety, which has a certain clinical application value.