目的 探究舒血寧注射液聯(lián)合胞磷膽堿鈉注射液治療突發(fā)性耳聾的有效性和安全性。方法 選取陜西中醫(yī)藥大學(xué)附屬醫(yī)院2015年2月-2017年2月收治突發(fā)性耳聾患者97例，隨機分成對照組（48例）和治療組（49例）。對照組患者靜脈滴注胞磷膽堿鈉注射液，0.25 g加入5%葡萄糖注射液250 mL，1次/d；治療組在對照組的基礎(chǔ)上靜脈滴注舒血寧注射液，10 mL加入5%葡萄糖注射液250 mL，1次/d。所有患者均規(guī)律治療14 d。觀察兩組患者臨床療效，比較治療前后兩組患者平均聽閾和聽力改善情況以及純音電測聽力圖分型的分布、治療后有效耳數(shù)和不良反應(yīng)情況。結(jié)果 治療后，對照組和治療組的臨床總有效率分別為73.58%、94.44%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者平均聽閾值明顯降低（P<0.05）；且治療組平均聽閾值比對照組更低（P<0.05）。治療后，治療組聽力改善情況明顯優(yōu)于對照組（P<0.05）。治療后，兩組患者上升型、平坦型、盆型患耳顯著少于治療前，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療后治療組上升型、下降型、平坦型、盆型以及總耳的有效率顯著高于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療組患者不良反應(yīng)發(fā)生率為8.16%，明顯低于對照組的25.00%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 舒血寧注射液聯(lián)合胞磷膽堿鈉注射液治療突發(fā)性耳聾具有明顯療效，安全性較高，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical efficacy and safety of Shuxuening Injection combined with citicoline sodium in treatment of sudden deafness. Methods Patients (97 cases) with sudden deafness in the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from February 2015 to February 2017 were randomly divided into control (48 cases) and treatment (49 cases) groups. Patients in the control group were iv administered with Citicoline Sodium Injection, 0.25 g added into 5% glucose injection 250 mL, once daily. Patients in the treatment group were iv administered with Shuxuening Injection on the basis of the control group, 10 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, the average hearing threshold and the improvement of hearing, the distribution of pure tone audiometry and effective ears, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 73.58% and 94.44%, respectively, and there were differences between two groups (P<0.05). After treatment, the average hearing threshold in two groups was significantly decreased (P<0.05). And the average hearing threshold in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the improvement of hearing in the treatment group was significantly better than that in the control group (P<0.05). After treatment, the ascending ears, flat ears, and pot ears in two groups were less than those before treatment, and there was difference between two groups (P<0.05). And the effective rate of the ascending ears, declining ears, flat ears, pot ears, and all effective ears in the treatment group were significantly higher than that in the control group, with significant difference between two groups (P<0.05). During the treatment, the incidence of adverse reactions in the treatment was 8.16%, which was significantly lower than 25.00% in the control group, with significant difference between two groups (P<0.05). Conclusion Shuxuening Injection combined with citicoline sodium have obviously curative effect in treatment of sudden deafness with high safety, which has a certain clinical application value.